ID V4AIL3_LOTGI Unreviewed; 783 AA.
AC V4AIL3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Calx-beta domain-containing protein {ECO:0000259|SMART:SM00237};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_91958 {ECO:0000313|EMBL:ESP03914.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03914.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP03914.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR EMBL; KB199905; ESP03914.1; -; Genomic_DNA.
DR RefSeq; XP_009045396.1; XM_009047148.1.
DR AlphaFoldDB; V4AIL3; -.
DR EnsemblMetazoa; LotgiT91958; LotgiP91958; LotgiG91958.
DR GeneID; 20252936; -.
DR KEGG; lgi:LOTGIDRAFT_91958; -.
DR CTD; 20252936; -.
DR HOGENOM; CLU_012872_1_0_1; -.
DR OMA; CMVGLKD; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878:SF76; NA_CA EXCHANGERS; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..400
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 415..514
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESP03914.1"
FT NON_TER 783
FT /evidence="ECO:0000313|EMBL:ESP03914.1"
SQ SEQUENCE 783 AA; 86759 MW; 4E5A10B505327442 CRC64;
RSAIYFFALL YSFLGISIIA DIFMRSIETI TSRTSTITVA DRFHGTREVT VKFWNGTVAN
LTLMALGSSA PEILLSIIEI VGNGFKAGAL GPGTIVGSAA FNMLCITGIC VMCLPEGETR
RIRSIKVFAV TCIFSVFAYI WLIVILVLVT PNYIDLWEAI LTLLFFPILV ILAYIVDKDF
CNKKSAVGAS ETELGIGKVT LPKLECGHMG KVSDLTDQWT ISDLYNTHYR HYRHQQKHIL
SEEDEARIAA GIIAKNTPHD RGWYRMNAIR QMTGHAKLNP QLNNKQSEKI VHDVNFDSID
KEDDEVDGGP LAVVEFAATS TAVLEKEGRA KVILTRHGNT ENRVLARIET IDGTAEANSD
YIPVKTTVVF EPGETSKHID IEIIDDNIYE PDEVFFIKVN VETDQEAITG SRAICQITIL
NDDEPGTFEF EKPSYVFKES IGVASIPILR SHGADGRVML KWKTKDMTAI SNRDYEGGDG
QLIFEHGEMV KMVEIPIHDD HVFEKDEHFE LAIDQLSEGA KYGRIKRTIV TIMNDDEFKG
VVSRIVNMTN ANLDAIKLET ITWGQQFHQA MNVNGGDTEN ATSFDYVMHF LMFGWKVIFA
IVPPPSIWGG WLSFFVSLAF IGLLTAIVGD LAGIFGCLID LKDEVTAITF VALGTSLPDL
FASRQAAINE KYADDSVGNV TGSNSVNVFL GLGLSWVIAA SYWSVKGQTF NVNAGSLSVS
VILYTVCALL AILLLLIRRY TAVFGKAELG GPTIPKYGSA MFLIFLWIFY VIMSSLEVYE
YVD
//
