ID V4AJE4_LOTGI Unreviewed; 694 AA.
AC V4AJE4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_104663 {ECO:0000313|EMBL:ESO93681.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO93681.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO93681.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; KB201890; ESO93681.1; -; Genomic_DNA.
DR RefSeq; XP_009055316.1; XM_009057068.1.
DR AlphaFoldDB; V4AJE4; -.
DR STRING; 225164.V4AJE4; -.
DR EnsemblMetazoa; LotgiT104663; LotgiP104663; LotgiG104663.
DR GeneID; 20229890; -.
DR KEGG; lgi:LOTGIDRAFT_104663; -.
DR CTD; 20229890; -.
DR HOGENOM; CLU_024257_0_0_1; -.
DR OMA; ECVYPGV; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..192
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESO93681.1"
SQ SEQUENCE 694 AA; 78493 MW; 2FB6529A4624BA1B CRC64;
KEKIYIDLQT QNACFRVLNA THQVGCSSKS GGNVGTLHYL ESEEDYNWVL KSGPHTPYIV
LITSLDFRKD NVERLVNTKR VNGILVLNIL NNQSLSPIPT EGFSADKSCP NDNYGIYSNS
SDYQHCKKVK WNAAGDGLYF KDYHDFPMFA ISNVTDFNVL VDQCYRKFNK PINGTARSFP
ICAAQLNDRM DAAKDTITCI RRSNHMTNLK QTRYCDAMGD KNIVATTKMV DKSEQRLNKS
VVVVSTRMDS FSMFEYEYQN SDTTVTGIVA LLSAAKALRP VRQILQNASK DLMFTFFQGE
AFDYIGSSRM VYEMEKNSFP YEIKDDVKSS QIVKLPSISH IIELAQLGHR DEGKLWIHTD
PISRGSGSAS EIEKMIKYIK DIGTEENVSL DDVGPDQPLP PASVQRFLKK ANIPAIVLTD
HKQQYTNKFY NSRLDLPDFI NASYPDDLNE TEKYDYVTEQ AKALTHVSTV LAQFLYKLTT
GEDITPNISQ QIQADELEIA HLLYCFLENP VCELFKQSVS PEDSDDLTKK PFPFYVSVDS
NTNQITRLTH SILAQYLGER LVNSTKDDCK QPDSDKVCHF ILYNYLWMEG SIKSGSSDRE
GWCIKSTAIL SKAQSPAFII DNYDWLSEEY STWTESVWSV FKVRVFLIPS ESQKVLTFCV
GFGILLVSLV VLYLLSISAD ILFMSAATSD SQPS
//
