ID V4AJQ2_LOTGI Unreviewed; 1433 AA.
AC V4AJQ2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_136183 {ECO:0000313|EMBL:ESP04399.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP04399.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP04399.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB199753; ESP04399.1; -; Genomic_DNA.
DR RefSeq; XP_009044885.1; XM_009046637.1.
DR STRING; 225164.V4AJQ2; -.
DR EnsemblMetazoa; LotgiT136183; LotgiP136183; LotgiG136183.
DR GeneID; 20233775; -.
DR KEGG; lgi:LOTGIDRAFT_136183; -.
DR CTD; 20233775; -.
DR HOGENOM; CLU_000162_4_0_1; -.
DR OMA; DSARCTT; -.
DR OrthoDB; 5490807at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:UniProt.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05495; Bromo_cbp_like; 1.
DR CDD; cd15557; PHD_CBP_p300; 1.
DR CDD; cd15802; RING_CBP-p300; 1.
DR CDD; cd02337; ZZ_CBP; 1.
DR Gene3D; 2.10.110.40; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR Gene3D; 1.20.1020.10; TAZ domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR031162; CBP_P300_HAT.
DR InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR InterPro; IPR003101; KIX_dom.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR010303; RING_CBP-p300.
DR InterPro; IPR038547; RING_CBP-p300_sf.
DR InterPro; IPR035898; TAZ_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000197; Znf_TAZ.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR PANTHER; PTHR13808:SF1; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF08214; HAT_KAT11; 1.
DR Pfam; PF02172; KIX; 1.
DR Pfam; PF06001; RING_CBP-p300; 1.
DR Pfam; PF02135; zf-TAZ; 2.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM01250; KAT11; 1.
DR SMART; SM00551; ZnF_TAZ; 2.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF47040; Kix domain of CBP (creb binding protein); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF57933; TAZ domain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51727; CBP_P300_HAT; 1.
DR PROSITE; PS50952; KIX; 1.
DR PROSITE; PS50134; ZF_TAZ; 2.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00203}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00203};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1..86
FT /note="TAZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50134"
FT DOMAIN 204..283
FT /note="KIX"
FT /evidence="ECO:0000259|PROSITE:PS50952"
FT DOMAIN 665..737
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 884..1260
FT /note="CBP/p300-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51727"
FT DOMAIN 1262..1310
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 1323..1404
FT /note="TAZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50134"
FT ZN_FING 1..86
FT /note="TAZ-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT ZN_FING 1323..1404
FT /note="TAZ-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT REGION 285..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1117..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESP04399.1"
FT NON_TER 1433
FT /evidence="ECO:0000313|EMBL:ESP04399.1"
SQ SEQUENCE 1433 AA; 160885 MW; BCF96F1CA92B192F CRC64;
DPDKSKLIQQ QLVLLLHAHK CQRRENANGE QACALPYCRT MKNVLTHMTS CTAGKTCQIA
HCASSRQIIT HWKNCHRNDC PVCLPLKHAS DNRRNPAGKY LTSISVVGGG NMAPNTNMTA
PSTLNAVPQG SGNVSETTFK RAVDALGLSN RPQPPVPPSA TTTLNQQNQN NALQAIIGPG
GMAQPPTMTA ASSEALQNIA MTSQMTKDWH QDVTQDLRNH LVHKLVQAIF PTPDPTALKD
TRMKNLVAYA RKVEGDMYET ANSREEYYHL LAEKIYKIQK ELDEKRQQRI RSGQPGPPGP
PGVPQPRANA PQNGPLSGFN AAESLGLTNL VPGLNNLFNH QQQQQLLQGS QVNPMAPRMP
GNQQLMSPPL SQQLQNNSQS QQLMQQTGQG GQPPSSVSQI HQSLSKILTP QNQTPTSTVQ
SNSLNQASAQ SATGLPQQQS QQQQQSGSGK QQNQSLGGLM GPGSVPNGTQ LGQGGPTSVG
KTLPVATSPA PVVSTASSSI NHVSLAYYLL YVNSMEVKKE IKTEPTSNSL SSLLSSPSKD
MSSTTNADPP SSVSNGTGVK TEIKNEPGVV KTEPSEAMDT TSAPPSVTPK PEGGSEGTTV
AEADTKPDTE DSSQGAPSTP VPTAPKSKKN TVESRLLKIF NSVFSVFKPD ELRQALMPTL
EKLYRQDPES LPFRQPVDPV QLQIPDYYDI VTKPIDLSTI KRKLDTGQYN DPWEYVDDVW
LMFENAWVYN RKTSRVYKFC SKLAEVFESE IDSVMQSLGY CCGHKYTFSP QVLCCYGKQL
CTIPRDSMYR SYQNRYVFCE RCFQEIQGDE VELSDDPTQV ATRIKKDQFT LQKNDQMDYE
QFVNCIECGR KHHVICALWF EPIWPTYTCD NCLKAKGMKR KENRFSAKKL PTTKMGNFLE
NRVNNYLKKK DVGAGDVSIR VLSSSDKIVE VKPGMKSKFP DEVPDSFPYR SKAMFAFEEI
DGVDVCFFGM HVQEYGSECQ MPNTRRVYIS YLDSVHFFQP RHLRTAVYHE ILIGYLEYAK
NMGYTVAHIW ACPPSEGDDY IFHCHPPEQK IPKPKRLQDW YKKMLDKAII ERVCTDYKDI
LKDAIENNFQ SATEMAYFEG DFWPNVVEES IKELNQEEEE KKKREEAQAA AAEAEAADCN
DEAEGSNKGR NKKAYKSKNN QRKVAKKSNV PQGSNDLTNK LYQTMEKHKE VFFVIRLHPQ
QNPPGMPQIR DLDPLCSCEL MDGRDSFLTL AREKHYEFSS FRRAKYSTLA MLYELHNQGK
DAFCYTCNEC KNHVETRYHC SVCEDFDLCV NCYKKVTHPH RMDKLGFDLD DGSYSGEKQE
NPQESRRQSI QRCIQSLVHA CQCRDANCRL PSCTKMKRIV HHTKTCKRKT NGGCPICKQL
IALCCYHAKH CNEGKCQVPF CTHLKHKLRH QQLQQRLQQA QLLRRRMAIM TAT
//
