ID V4AK80_LOTGI Unreviewed; 775 AA.
AC V4AK80;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=LOTGIDRAFT_170693 {ECO:0000313|EMBL:ESP04604.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP04604.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP04604.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KB199699; ESP04604.1; -; Genomic_DNA.
DR RefSeq; XP_009044773.1; XM_009046525.1.
DR AlphaFoldDB; V4AK80; -.
DR EnsemblMetazoa; LotgiT170693; LotgiP170693; LotgiG170693.
DR GeneID; 20241490; -.
DR KEGG; lgi:LOTGIDRAFT_170693; -.
DR CTD; 20241490; -.
DR HOGENOM; CLU_361039_0_0_1; -.
DR OMA; RICETIM; -.
DR OrthoDB; 2961687at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 498..585
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
FT COILED 703..737
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 775 AA; 89989 MW; 2B60A898FFEC6982 CRC64;
MAYQLRLGDR KYSRRFHTNS VYLNVDFTQN WNNVLPAEVP QQLDNTFNQI IRDIGNYLSC
DPDDQVRFSV SHPGLKSPAW IPFNKWSGIR AQDILNPVAR ILQSNEQFRL DERMTLHVCH
VSVPKGDGQG RYLLKRESLS LEDYLKRKRS IVVVKNKDNL CFQRAIVIAK HYANKNDTPE
WETQRKRLTK SSGPYSWQTK CTERLIEQVG ARPEACQGHE TWELYQQTLG QQGYQLFVYS
RLLFGKLLYK GKVSGTPKKL HLYHHDHHYD VIVSMPAFLE RNYYCDLCGK GYNNIETHTC
ISVCSACRRP GKDCPTDTLR DCLECHRTFF SEECFKAHKT GTTLNAITTC NKWKKCTKCC
KEWDTRKRGR LLEEHICGEY ECKICRKWHG KGDKWCYIQT IDIDKTKVEE KQDKDVTRFV
FYDFECHQNT GEHIPNLCVL QLCCHFCIGQ STPCQHCDST WNHQKEIIFS GPNTLDEVAK
FFVHLSAKKV APGGCATTKS QNIVAVAHNF RGYDGMIILQ GLHKHAMDVP KVILNGGKVM
TIQLGCVKFV DSLNFLAMPL RDLPKTFGIT ELKKGYFPHF FNKPENAQYV GDYPPVTDYD
PDGMSVGERE KMDQYILLNG VRLGSRFSFI IEWFRVLIGE GRRGVNSQQD EIKINRAPPV
SPKDVHAPEE LLCNPSESRQ YERKRNEEKR WEDRTSLVST RTVNESSAEI LNLRNENNGF
KEELARNQMV CDRLEEQIDR NDNKWRQNNI LIYGLKVDNS SQVENEVWWR LGVER
//
