ID V4ALC2_LOTGI Unreviewed; 1535 AA.
AC V4ALC2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN ORFNames=LOTGIDRAFT_103875 {ECO:0000313|EMBL:ESO97902.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO97902.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO97902.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR EMBL; KB201304; ESO97902.1; -; Genomic_DNA.
DR RefSeq; XP_009051742.1; XM_009053494.1.
DR STRING; 225164.V4ALC2; -.
DR EnsemblMetazoa; LotgiT103875; LotgiP103875; LotgiG103875.
DR GeneID; 20229797; -.
DR KEGG; lgi:LOTGIDRAFT_103875; -.
DR CTD; 20229797; -.
DR HOGENOM; CLU_001270_0_0_1; -.
DR OMA; KILCLWR; -.
DR OrthoDB; 24616at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 15..547
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 112..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1535 AA; 172667 MW; 172C40807956FF8B CRC64;
MSELHKKYFC PRLLDYIVIT GSRNPNNNNN VAQTPELLRR YPLEDHKDFP LPTDVIFFCQ
PEGCISVGPK RMSLRETTSF VFTLTEKDSG IVRYGICVNF FRPFEKRSHT TSVDWQNKER
NSSLASTHSV DTVSSTESDK PKSPRARRKG GPSCRVRNNT LTSLCIVSHH PFFSTFRECL
FILRRLIDAC HDRSCVRRIG GSKGATRDTV WGVLTGQCSD NITSLVMHDV REIETWILRL
LSAPVPVPGK TRVEVHILPK DLQAPLLFAL PDNTRFTLID FPLHLPLELL GVDTCLKVLT
AVMLEHKVIL QSRDYNALSM SVMAFVYMLY PLEYMFPVIP LLPTCMSSAE QLLSAPTPYL
IGVPASFFLY KKGFLLPEDI WIVDLDSNKI HPPSKAEPLP SLPDPEGAVL KTHLKQALAS
MSMTPQPIKN LDALAQNAEI WQRRESFSSQ TGFNPLIYGN DVDSVDVATR VAMIRFFNSS
NILGNFCEHT RTLRLYPRPV VAFQLYSFLK SRQVRTHFSV RLARTQAVEY YAEWSLSPQN
LVYLRVHTGV YDPSLIGDKP KWYAHQLQSV EFHVYDPNSS LSAALNSVSD VLSDEIPTDE
SGSDSEGAES TSSSYSSLSD FVTDMVNSEI DGETPAAFIP ENQILAVDES KVFTPPDKLH
VPDVNATNSD SALSLPEDSD VSSSASSSPT YSDNIPRSER EDKDLEDIKI LLGAVLPGPS
EAPRSPKLPS FTKSTNSAFD VYEKPKPLLA LIPPNPNMMR AQRGSVSSSS STSTTKGNLR
VPNISDHESD RSSSPSSIIS TISNELTDMA QSATHTMSEL FGNGNNSNKP QSKPFTPLGK
LIYFLIYQLL HIYASVEKSG LVKQSSIGKK PKEPSPKPSP TDSRSSSNSE NQQFLKDVVN
NVMEGQGTSW LKMGRVKTLM EDENYRNFVV SRLNKNLDKK VTDESLHIDD VCVSRQVFKG
MLAMLKAIIH GLEKTFQNHG LGGTASAYMV LEIAHTHYWY REPALYKSES SLTPDVSGKP
DHKKYFNLRS PVIVNGDEYE NIEIHPDVNL NMRSLDNVQG SRQDQNRNVH KHSCDIIVTD
HDIPSANTRS GDMLHEMVKN KELIKASRLD KISSVDSEMS DASTLVSTCS DDERKKSRIN
HHSIKSSMSD SEADPSGVSY FFDELFILHS LELYVESKLI STSTTTNTET GRTFLFEGLL
GKERSRLWDQ MQFWEDVFLD AVAQERDIIG MDQSPSEMMD RYASLGDMER KRLEHDEDKI
LATILFNLVS FMVMLRVNKT EIKKKSRRLL GKSHIGLIHS QEVNNLLDQI TMLHGNDIDL
KPICSRQMQK QSFTVHWGTD NTGDMLFMEV CDDCLLLRSV TGSIHDRWWF EKLVNMTYCP
KTKVLCLWRK NGEKVQLNQF YTKKCKELYF CVKEAMEKAA ARNSGKLPGP ELGGEFPVQD
LKSGQGGLLQ VCMEGIGLLL ANSKFFIELA HIRKCFTLKG GIFVLEEFDT KNKKIIQHKF
KSRMADQMCY AVLCLFSYVA AGVEQKKQQP QQTSS
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