ID V4ALL5_LOTGI Unreviewed; 477 AA.
AC V4ALL5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO98007.1};
GN ORFNames=LOTGIDRAFT_174471 {ECO:0000313|EMBL:ESO98007.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98007.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98007.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; KB201294; ESO98007.1; -; Genomic_DNA.
DR RefSeq; XP_009051302.1; XM_009053054.1.
DR AlphaFoldDB; V4ALL5; -.
DR EnsemblMetazoa; LotgiT174471; LotgiP174471; LotgiG174471.
DR GeneID; 20242751; -.
DR KEGG; lgi:LOTGIDRAFT_174471; -.
DR CTD; 20242751; -.
DR HOGENOM; CLU_020415_3_2_1; -.
DR OMA; TIFRLAW; -.
DR OrthoDB; 3414706at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 477 AA; 54650 MW; 841F7BCB3946AC50 CRC64;
MSVKAIPSAE PMLKFANDAD DVVQMYGKSA TIHGVHAIIT PQAFKWRRYV WLLLLIGMTF
SLSFFLYLQF KKYASHPVVS SINVEFTDDL KLPDITICNS NNFHRDRIPD EPILKELLFN
MSDLNYLRYQ LNGTARPSTP KSTDSFTGPY LRKFAEDATH KVKDMFMVCE WQYKSLNCSR
YLRKRFTDFG VCYTLTSNQD SPIALPVLSP SNTANNLRLI VNIEQDKYYY SRSSQSGIKV
VLHEQNTEPS PFQHGFYVQP GTSTSVTFGI TKYSWLPEPY KAFGNTSCEE IDDRTFKTEN
NTYQYSKDAC VSNCIRNYLF KQCNCNFFLN RGPEPFCSLT ELQDCLFPHM HNISHAHISN
CHCPTPCQVT EYEARLSVAN FASTFIKDYL VNINLIKSAD TIDENLIDLR IQYSAVSAII
KQQKPEITIE GILGNLGGHM GLFIGASVMS LFELLEFLII YLHQLCKHGF QKTRKKK
//
