ID V4ALR2_LOTGI Unreviewed; 307 AA.
AC V4ALR2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein {ECO:0000259|Pfam:PF15361};
GN ORFNames=LOTGIDRAFT_151923 {ECO:0000313|EMBL:ESP05124.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP05124.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP05124.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the ric-3 family.
CC {ECO:0000256|ARBA:ARBA00008538}.
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DR EMBL; KB199650; ESP05124.1; -; Genomic_DNA.
DR RefSeq; XP_009043669.1; XM_009045421.1.
DR AlphaFoldDB; V4ALR2; -.
DR STRING; 225164.V4ALR2; -.
DR EnsemblMetazoa; LotgiT151923; LotgiP151923; LotgiG151923.
DR GeneID; 20235558; -.
DR KEGG; lgi:LOTGIDRAFT_151923; -.
DR CTD; 20235558; -.
DR HOGENOM; CLU_907000_0_0_1; -.
DR OMA; DSTESCA; -.
DR OrthoDB; 2969701at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026160; Ric3.
DR InterPro; IPR032763; RIC3_N.
DR PANTHER; PTHR21723; RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3; 1.
DR PANTHER; PTHR21723:SF3; RIC3 ACETYLCHOLINE RECEPTOR CHAPERONE, ISOFORM C; 1.
DR Pfam; PF15361; RIC3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..146
FT /note="Resistance to inhibitors of cholinesterase protein 3
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15361"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..154
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 184..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33561 MW; 555D8B0CB776F5DD CRC64;
MAGSRPDMRP HMRPGPPPGL RAAAEMERER AQQGGGRGMM GVVLPMYAVG IVLYLIYTLV
KVFNKNSGEE RQDDLTEYLN KDPASVYDTG PLDTEAKMEE FLKQQKTNEL EKLLIKADDK
NISSGEMRAL QKRLEETEAQ MTQILQAMQA VSHKVEDVAS ANPDVQDVLK SAGGTPSSPS
NDEKASEDNQ EGEKSGKSTD SSPDMDSFEI VGKKDSNATS DQSNNTEDDI SQSLSSEVEN
IGQHDSQIKM TESDSTESCA GEKDNSVAPE SERDETGADG SEELLPEEDT QHDTTVRHRN
VETSNNS
//
