ID V4ANK1_LOTGI Unreviewed; 513 AA.
AC V4ANK1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=LOTGIDRAFT_176681 {ECO:0000313|EMBL:ESO95211.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO95211.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO95211.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB201680; ESO95211.1; -; Genomic_DNA.
DR RefSeq; XP_009054101.1; XM_009055853.1.
DR AlphaFoldDB; V4ANK1; -.
DR STRING; 225164.V4ANK1; -.
DR GeneID; 20243920; -.
DR KEGG; lgi:LOTGIDRAFT_176681; -.
DR CTD; 20243920; -.
DR OMA; CANISCE; -.
DR OrthoDB; 4257264at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 372..513
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 513 AA; 60250 MW; E491F7C6786A312A CRC64;
MVFMDKMFTH LPHLKELNFS NNHIEYMTLS PSTTLTTFRL SGNHLTKFPK FCEQSKALFP
NLQKLYIDRN CIYKIASSRI DCLKKLKYLN ISELHMEIIP NNLFSKLTSL RRLYIEHSDS
LKSIHPLAFN SSSLDTLFIR SNKLFFYEPY VNPRSILANT PNLKYLDISD NILGKMSERD
WTEMLKCVPK LLFLGISMGE IEKLPEVVPG YLHNLNDFRA EYNGITKIPA NYLSPLKKLL
QLYLNDNKLS KINEGDLPKS LEIINLAFNP FVCDCRLLWF KNFIEKNPQI FPYYPRLYLC
ENEKPLADFR ITIKSCLFSQ KINNIIMSTS LGLVCLVLGF SVVYHYRWRL RYFVHVLNLH
RRKYFSSNGQ RFLYDIYVVC ANISCEEVYI RENLVTILEN DGKTVFFPRR DASPNKPTVT
QTLEQMDRSK CILICISDAF SSDQLCEFQV NMALERSIHD RDCTVIVVIL EELSPDNVNK
TINHLLRTHQ NYLLWDEEVE ANALFWRKFN EYI
//
