ID V4ASU3_LOTGI Unreviewed; 1178 AA.
AC V4ASU3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=LOTGIDRAFT_238609 {ECO:0000313|EMBL:ESP00328.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP00328.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP00328.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB200766; ESP00328.1; -; Genomic_DNA.
DR RefSeq; XP_009049008.1; XM_009050760.1.
DR AlphaFoldDB; V4ASU3; -.
DR STRING; 225164.V4ASU3; -.
DR EnsemblMetazoa; LotgiT238609; LotgiP238609; LotgiG238609.
DR GeneID; 20250805; -.
DR KEGG; lgi:LOTGIDRAFT_238609; -.
DR CTD; 20250805; -.
DR HOGENOM; CLU_273352_0_0_1; -.
DR OMA; TACEIDH; -.
DR OrthoDB; 2898421at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 10.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF30; DELTA-LIKE PROTEIN; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 5.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 16.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 11.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 11.
DR PROSITE; PS50026; EGF_3; 16.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1178
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004716284"
FT DOMAIN 244..280
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 282..318
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 320..356
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 358..394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 396..432
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 434..472
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 474..510
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 512..548
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 583..618
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 653..688
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 689..723
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 758..793
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 795..831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 833..869
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 871..907
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 909..946
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 959..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 270..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 308..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 346..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 384..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 462..471
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 500..509
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 538..547
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 587..597
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 608..617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 657..667
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 678..687
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..702
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 713..722
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 762..772
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 783..792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 821..830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 859..868
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 897..906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 936..945
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1178 AA; 127440 MW; 1FB36F374C54A6E1 CRC64;
MVAPLFYSFL VLGLLFLSIP AVTPKGVIKV QLRTFKNPGG KGNNGHCCDG RWIFCGSACD
HRFEICLDKV NGDHRITSCQ YGKITTKDVP DRNYIYFGSS IGGVRNPMVF TLNSIPSSIR
VKIGVWDVDD SSSHDYVGYL YKNINLTPGK SEYIMLSNRI VLTGNVWSAC LPDYYGSDCS
VYCKASSNMW GFYTCDKTTG AKKCLAGFVE ILKPFYLEEK IQNGCELRLF VLFPGYTGRN
CAVRTNECQS NPCRNGGTCL DGHLNYSCKC LKGFTGAQCE VNIDECASSP CLHGGLCVDS
VANYTCQCTK GWTGTNCQLD INECSSSPCQ NNGVCRNEVA EYRCECQEGF TGGQCETNIN
ECENSPCRHS GTCIDLINGY TCICSQGMKG DNCEINIDDC EVNPCHNRAI CLDLIADYFC
ACPTGFTGKE CQTNINDCEY YSQPCQNGGS CIDGIDDYAC QCLPGYEGYN CAIDVDECLS
SPCKNNGSCL DGINEYSCTC SLGYTGRDCE VDIDDCKDNS CVNNGTCVDA PASFSCLCDT
GFTGEYCEMD YCEYADCGNG TCVRQVDGYN CSCDPGITGV SCETDLCADS PCGNGTCVRS
LNGYNCSCDL GFSGTACEID HCEGATCGNG TCVRQSDGYN CSCGLGFSGT ACEIDHCEGA
TCGNGTCVRQ SDGYNCSCEL GFSGTACEID HCEGATCGNG TCVRQSDEYN CSCDLGFSGT
ACEIDHCEVA TCGNGMCIRQ SDGYNCSCDY GFVGISCETD LCLDSPCGNG TCVPLSNDYT
CSCDVGFTGQ RCDINIDDCE ANLCQNSASC TDGVDSFICE CLVGFTGQYC ESEIDHCQFN
NCADGSSCVN SQESYSCICA EGTTGKSCEQ NIDSCDPDPC TNNSTCVDQL TGFVCLCQSY
STGLLCDTLI SPCEDSPCIN NGTCVEEDVS NFTCSCTDEW TGPTCNERII EVAFTTDTSG
LETSSPVPST TSPTNAPFST GSDDLPDATG RQLIKPMASY LNWFDRGEFV FSKKAKLANF
NICLWYQNPF SHSQWGLPPY EWGLVSVGGL VVVSVVGQVG GYLWIGRLCC RSGCSIAVFT
IELIHHGWIP FLFSVSSIVA RLQLRTTWLD MVCNLGFWRC IQIELHYIRI KCLWCGMEAP
RIRKGESSDN LPTHYSTATI GVFWGHGLYD PTDPPIHR
//
