ID   V4ASW8_LOTGI            Unreviewed;       710 AA.
AC   V4ASW8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESP00343.1};
GN   ORFNames=LOTGIDRAFT_238585 {ECO:0000313|EMBL:ESP00343.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP00343.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESP00343.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; KB200750; ESP00343.1; -; Genomic_DNA.
DR   RefSeq; XP_009048960.1; XM_009050712.1.
DR   AlphaFoldDB; V4ASW8; -.
DR   EnsemblMetazoa; LotgiT238585; LotgiP238585; LotgiG238585.
DR   GeneID; 20250796; -.
DR   KEGG; lgi:LOTGIDRAFT_238585; -.
DR   CTD; 20250796; -.
DR   HOGENOM; CLU_388970_0_0_1; -.
DR   OMA; LETSIWI; -.
DR   OrthoDB; 2971810at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        80..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        494..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          536..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..550
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..570
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  81311 MW;  12AF2437A73FE157 CRC64;
     MRDVKMLGEE KWKEKCDRYF SSMGDLTEQK SNNTRRELLP ASDSDTILSK RNRQSIRKWV
     NGLDLHGSSF LSASRSKFTM AIWLILILFS LASYGLLTYL LINDYFHQAP KLVLTSATRE
     THIDPSLSVT FCNLNILKVS KLSATRFEKL RNLLPKTVNA NAPQTDRNSA PLSDMLRTTN
     LWETLQSNLG ENLTSFLSEI EHEFSAYENQ ETDQDLESLY HAALEGDLSS IYDALRLSRH
     DIQSLGHQRT EMLRHCWING RNCLESEMKV FVDSQKGNCV TVKSSSKMDG FERLSLLLDT
     EPYEYVGVTS PVTGFVVSVH DSNINHDETS QFITSPGENL NLKIHQVSRY HRITGCTTDP
     YHNQQTCLQR CLGKNIIKTC GCSISLDAAL KTRCRYNIPY EYVCKRSMEY LIKKGRLNCD
     CPKRCRERQY DIRSTRGDWP SRFHSVHIER SLAAKGLTRN YAQLRETMVK VDIDTTQAQF
     TDYKEQYDIT WLGLLWRMGG LSAMFIGISA LSILEIIWLL GRSVTVCCTT FRRKATPKVK
     DEEDEEAHST WENNQATPKL QPTVNKPTQR PRLPSLPVET RPSNNLGPIP EDFSHIENNF
     ITLNDDYDEI DHIYAQVWDP TTSGQIQNGG LENNVNAVTN RLSGKKSNYN IKVNNKSQDA
     KRNYFTRAEG SAPDNRQRNR IITPHLVQTY STHQTQTRLV TGTRPGIFYM
//