ID V4AUT9_LOTGI Unreviewed; 525 AA.
AC V4AUT9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
GN ORFNames=LOTGIDRAFT_231148 {ECO:0000313|EMBL:ESO98730.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98730.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98730.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; KB201205; ESO98730.1; -; Genomic_DNA.
DR RefSeq; XP_009050372.1; XM_009052124.1.
DR AlphaFoldDB; V4AUT9; -.
DR EnsemblMetazoa; LotgiT231148; LotgiP231148; LotgiG231148.
DR GeneID; 20248491; -.
DR KEGG; lgi:LOTGIDRAFT_231148; -.
DR CTD; 20248491; -.
DR HOGENOM; CLU_519048_0_0_1; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 2.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF13; TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 2.
DR SUPFAM; SSF49842; TNF-like; 2.
DR PROSITE; PS50049; TNF_2; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..248
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT DOMAIN 381..507
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 525 AA; 61172 MW; 7274EA8497CCA0E3 CRC64;
MKHNEKYERW AVYISVFISI ASITSSGFLL YLFSSTKAKL ADVFCVPCDK LNFSTFPNET
EKKYKMLDKD YENGEKVCCG STTQSTEALL DLISDRKLRE SKIQERNDEI RDGYIKGSQI
SAHILMSGYD DKLQEKRPAE LLKDRKLSHF NGVNITHDRI NIRTKGKYFL YCQLYFKVIL
GTNLDKQEGI LSYQIRRYNS KLPNYYTEKL LESKFTVQFK DGKIDDNDNK TDFLSGIFNF
EAGDQLYVMY LEEEMSRTDK SIRDKYRRRT VYLSVFISIA SITSSGFLLY LFSSTKAKLA
DVFCVPCDKL KCSTFPNETE KKCKMLDKDY ENGEKVCCGS TTQSTEALLD LISERKLRES
KIQDRNDEIR DGYIKGSQIS AHILMSGYDD KLQEKRPVEL LKDRKLSHFN GVNITHDRIN
IRTKGKYFLY CQLYFKVILG TNLDKQEGIL SYQIRRYNSK LPNYYTEKLL ESKFTVQFKD
GKIDDNDNKT DFLSGIFNFE AGDQLYVMDE SQHWLSSILL LPEIR
//
