ID V4AUW9_LOTGI Unreviewed; 1181 AA.
AC V4AUW9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_231163 {ECO:0000313|EMBL:ESO98770.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98770.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98770.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB201205; ESO98770.1; -; Genomic_DNA.
DR RefSeq; XP_009050407.1; XM_009052159.1.
DR AlphaFoldDB; V4AUW9; -.
DR STRING; 225164.V4AUW9; -.
DR EnsemblMetazoa; LotgiT231163; LotgiP231163; LotgiG231163.
DR GeneID; 20248496; -.
DR KEGG; lgi:LOTGIDRAFT_231163; -.
DR CTD; 20248496; -.
DR HOGENOM; CLU_001634_5_3_1; -.
DR OMA; YCIVERD; -.
DR OrthoDB; 4033541at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF179; LD23292P; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 491..627
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 767..860
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 374..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..396
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1181 AA; 133560 MW; 5A54D143A303D077 CRC64;
MRLFRCQDAR YMVLTPKSIQ SCVPYSFSAR AFGNHSYTLK AELQRSYSGN TISSITTEIL
PGDTNTITLQ VPCNLTSWSI YLILAGTGET TFYNRQYLSV NSKNMEIIIQ TDKKVYKPGQ
TVKYRVFGVR SDLQVVCSNY TVTVTDPKRN KIHLYTSAGD DYCIVERDLK LPKEPIFGAW
KIKASVEKME HTQTFKIEKY VLPKAEAKVI MPSIVSQKDN SITVQVSSQY TFGKPVNGSA
RLRIIVNYYP KRKYQKDPDT GKYGYVDLTQ PELIYDMQLD KNGKGTTVIT TEELKTIAYR
GYLSYKTIIG QVNVTDDTTE ATYISQTSQI SVTRTREKLS FVLNPQNYKP ALVNRLYIEL
KQIDGKPVLE PGNIIEEPAA EPPPPSENPD NSSTPTPPTT PRRRYGHHGW GYGRYGYPPW
YDPNCKDPQY RYENLPEKYL TVPANGLLTY DLLVNETDSV EVYLKVNYVE DTDVYTSRTL
TSFKSPSNTF LSVSLKTNKP ASGQKVELEL KATREFSRVY YTILSRGVLI TENHQDFSTP
SKSQILSFSV TSDMAPKLKI IVNIRVEDKE IVADAISFNV EGFYNNKVSL MFDSDKVETG
SISTLSVKAY SNSNVYAVAV DKSTTLLGEA SDDFSQEVKE FLDKVSSRNY YRKKRGALFG
KRSESEKRSR TKRSVWWPYA YTTSGTDVDD IFRYTGLNVI SDALVYKYQT PEPCRRYYGR
YGYPGTQPPA GTSATMPPEA FQPAQAPDVA SRNFDEEVSA RSFFPETWIW ESQNAGSIGI
ANFTLKVPDT ITTWVASAFA VSPNPLIGVG MTSDVAELTA FTEFFVMLNL PYSVVRGEEL
VIKASVFNNL GFDTEAEVML ENPKGFVIIQ VDADGFEVES MVTETTRINV PKDGAATAYF
TVRFLEVGYI DLQVYARTVT LQAGDRILKP MFVEVEGIPQ EYNEVVIVEL VEQNYFNRSV
EIRYPSNVVP DSQKVVVTAY GDPLSSALQD TEKWIKRPYG CGEQNMINFV PNIYTWAYLH
CTGQLTPAIQ TKIKNYLGIG YSGEMRYQRN DYSFSAFGDR DSSGSQWLTA YVVRTFSEAR
QYIYVDEKIL EYAVNYLINN QNEDGTFNEP GRVIHKELKG SSFEGNGLNA FTLIALSENS
EIMQQTTLGI VCDFSIHWKR TLTCHLPTNQ PSWDSEYSWG L
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