ID V4AVX1_LOTGI Unreviewed; 448 AA.
AC V4AVX1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=LOTGIDRAFT_239739 {ECO:0000313|EMBL:ESO99215.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO99215.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO99215.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KB201061; ESO99215.1; -; Genomic_DNA.
DR RefSeq; XP_009050097.1; XM_009051849.1.
DR AlphaFoldDB; V4AVX1; -.
DR STRING; 225164.V4AVX1; -.
DR EnsemblMetazoa; LotgiT239739; LotgiP239739; LotgiG239739.
DR GeneID; 20251153; -.
DR KEGG; lgi:LOTGIDRAFT_239739; -.
DR CTD; 20251153; -.
DR HOGENOM; CLU_726808_0_0_1; -.
DR OMA; WIIEWIS; -.
DR OrthoDB; 2962512at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF03175; DNA_pol_B_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 6..167
FT /note="DNA-directed DNA polymerase family B
FT mitochondria/virus"
FT /evidence="ECO:0000259|Pfam:PF03175"
SQ SEQUENCE 448 AA; 52095 MW; 3E020CF8AD38D3A6 CRC64;
MAVPKENEEI RYLDVVSLYP YICKYGRFPI NEPEIVVSPD QQNWQQYEGL IQCKVVPPRR
LYHPVLPFRW NNKTTFPLCR SCIMENMQES EISEYVPCAH SDDERALVGT YVSLELKKAA
SLGYKVIQVF EVWHWAEEKW SQYDTQTKTG GLFTGYIDHY LKTKMESSGY PSECRTDQEK
AQFIADVYQK EGISLDPAKV IYNNGMRSCS KLKLNILWGK FGQRDNFSQT EYITEPERYF
DLLTDVTQSI KDVQLVNDNM VMVERLKLEE HVQPSQITNV VIAAFVTAQA RLKLYSVLEP
LAERVCYFDT DSVIYVHHPD QWNPPRGNSL GEWKDELEEN VTITEFVSGG AKNYAYKLSN
GQTVCKVRGF TLNYRGSKDL NFDSVKGMVG NVQQNIPLVV TNPFKITRTR DRRLCTRSED
KQYKVIYTKR FIHFNDKNEP TNTYPYGF
//
