ID   V4AX82_LOTGI            Unreviewed;      1860 AA.
AC   V4AX82;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Lactase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_174304 {ECO:0000313|EMBL:ESO98171.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98171.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO98171.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
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DR   EMBL; KB201263; ESO98171.1; -; Genomic_DNA.
DR   RefSeq; XP_009051153.1; XM_009052905.1.
DR   STRING; 225164.V4AX82; -.
DR   EnsemblMetazoa; LotgiT174304; LotgiP174304; LotgiG174304.
DR   GeneID; 20242689; -.
DR   KEGG; lgi:LOTGIDRAFT_174304; -.
DR   CTD; 20242689; -.
DR   HOGENOM; CLU_236676_0_0_1; -.
DR   OMA; QITHYKV; -.
DR   OrthoDB; 3373839at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 4.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 4.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 4.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 1.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 3.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1860
FT                   /note="Lactase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004717042"
FT   REGION          833..852
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1817..1836
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        885
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   1860 AA;  212386 MW;  45CD8B1A4E9E988D CRC64;
     MVAVWMLLLA SFLLVAVVDG NDTYEDKFYF DTFPDGFAWG TATAAYQVEG AWNEDGKGES
     IWDRYSRIPG NVDDGSTGAI ACDSYHKYKE DVQMLKDIGA THYRFSISWP RILPDGTNKT
     INTKGIDYYN NLISELLKYN ITPVVTLYHW DLPQALMYKG GWLNEDNNKY FAEYARLCFQ
     HFGNRVNHWI TFNEPWVVSI QGHGIGDMAP GLKGLGTNTY IVAHNILKSH ALAFHIYDEE
     FRKTQKGQIG ITLSFSFAIP EDPGNPSDLE AAETANQFSF GWFAHPILVN GDYPEIMKSQ
     VHNKSMEIGL SQSRLPEFSD DDKANIKGTA DFLGLNHYTS VYATAMNLPA DPPSFFDDSD
     VKTFPDPEWP RSGSSWLRVY PKGFRAALNW LKKKYNNIPV YSTENGVSDR NDTLYDQNRI
     NYYRDYINEM LKAVKIDKCN VKGYFAWSLM DNVEWSRGTT EKFGMYRTDF TKPDRPRTPK
     ASSRYFRQIT KDNGFKPGYP GLSGMATGLV PYENEFLYDD FPKDFKWSTA TAAYQIEGGW
     NEGGKGLSIW DVFSHEQGHI VDNSTGDIAC DSYHRYKEDV KLLKELGVSY YRFSISWPRI
     LPNGTPDHTN QKGIDYYNKL IDDLLANGIQ PMASLYHWDL PHALQLKGGW LNDSIPDWFN
     DYAKICFEKF GDRVKYWMTI NEPSSISVIG YQVGVMAPGM KGGLKARYHV DYNLIRAHGR
     AYRLYEKDFK KTQKGKVSIV LSLNWAQPKN PLDDSDVQAA DRSMEFTGGI YENPIYGSGD
     YPEVVKRLVA EKSKAEGVPN KLPAFTPDEI KMLKGSADFF GMNFYTASLA TNDPSGKSEA
     NALSETDPRW KGSASSWLKV TPFAIRKMLN RVRRKYGDIG IFVTENGVSD STGTLYDTDR
     VHYLRSYTNE ILKAIKIDKV NVIGYTPWSL MDNFEWARGY TERFGLVYVN MSDPSRPRSA
     KLSARWFSQL TSENGFKRGY TAIGGRGLAV QKENEFYYGT FPKDFAWGVA TSAYQIEGGW
     NADGKGPSIW DTLTSKGLAN NGETGKIACD SYHLYKDDVQ KMVDLGLSHY RFSISWSRVL
     SDGTKSSRNQ LGIDYYKNLL KELDKNGIPP IVTLYHWDLP QALSDRGGWT KTFIQDAFVD
     YANLCFEEFG QWVKIWITFN EPQVFTTGDF DLRGQDGQVQ YQKAHNVIIS HAKAYRSYHK
     SYASKQHGKI SITLNGNWAE PLNPVSLSDY EASDWTMQFV YGWFGHPVYV DGDYPDIMKE
     RVGQISRKQG FNESRLPTFT DKEKSMINGS HDFIGLNLYS TDMVTKSSND AGKLKPDYGR
     DIGITGSKDP SWKRASATWL AVTPFAIRKL LNWAKINFGN EEIYITENGY SDLSGERNDT
     DRVEFYTLYL NEVLKAIDLD KINVKGYMAW SLLDNFEWRS GTSQKFGLYQ VDFTDPARPR
     KAKASAAFYY KLIKDNGFEP GSEIDPTPPQ LPYKEKLYMG EFPDDFSWGI STPELVTGQD
     YLSQIQNLQK IIGDYFIFSL SYSKIMKNEK AQDQIGIQYY NTVLDDILDV GVRPIVSLDL
     TNSNLNDFEI YAKICFEHFG DRVKSWITFR NPINSNDIDD PEIIHKMILT HAKIVHIYRQ
     QFQPKQKGQI GIGLKSQWYE PDDPFDPRSL RQRDIKVATR FDWIAHPIFL TGAYSEMLMK
     QMPTLKQFSL EESEMIKGSA DFMILDYNHT MIGHSINTNS IDLRHTLRLI KNRYNNPMVY
     LGDIGLNRLH YDDLFVYLFY PNQVLKAIRM DGCNIKGLSI DANTPPHSLQ QFSHLVKDNG
     FFKTLNQLNH NETMTIENST STITDARKQK TTPPGPVSKS NSVFKFILFP SLLTVFFVHI
//