ID V4B087_LOTGI Unreviewed; 640 AA.
AC V4B087;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN ORFNames=LOTGIDRAFT_171498 {ECO:0000313|EMBL:ESP03408.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03408.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP03408.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB200027; ESP03408.1; -; Genomic_DNA.
DR RefSeq; XP_009045941.1; XM_009047693.1.
DR AlphaFoldDB; V4B087; -.
DR EnsemblMetazoa; LotgiT171498; LotgiP171498; LotgiG171498.
DR GeneID; 20241803; -.
DR KEGG; lgi:LOTGIDRAFT_171498; -.
DR CTD; 20241803; -.
DR HOGENOM; CLU_362582_0_0_1; -.
DR OMA; CAKVMEN; -.
DR OrthoDB; 2970229at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 386..501
FT /note="TIR"
FT /evidence="ECO:0000259|Pfam:PF13676"
FT REGION 519..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 351..378
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 640 AA; 72470 MW; 65EFAB6326EE1DBD CRC64;
MEEYKAKEEA ALEEVKVAFK ELDDYLPKGN MDMVHGAIYK IRMLYSVMYS APPDFIAEYR
KKLAKLITAH GKFVPVVCDS IVKVIKENNF HGNDENPAAK KNYALIDMCN VSFLNYSDCS
DLFREQYGKQ EEVIKVMAEK LFEWAPGHIK GTLPAEEEKI VKRFLGIAHN LAILPENVNM
LRKYDYVKAI APYLESQSGM YTLSALATLA DILNEEECHL LQTNEGSIKF LLLKLGNASV
RSDRRDAGWS AAELGRTVGR LARNDGNKKL LVTLGALPLL LALTTSNIKI EQEESIEALW
VLAFDEENQP KMVAEPNLIE TIDKLRRTTE GNVKKLCNGI LWTLRNVLKV NNKFKHLVKN
FQEKLEREKT NLKKNESSDA EDQGHVMISY QWGHQNILKQ VSSELRKEKR IVWMDIDNME
GSTLQAMANA IEGAKVVICC MSQKYKDSPN CRAEAEYAFQ LRRPIIPLIM ERGYRPDGWL
GFILGAKLFY DFSGKYSFES RMDGLIKAVM QIYDPQSVGG DSAGPGGKDV MAPPPAMDEV
EGPPIQRQRA VKLYSSPQKP TEEDEKVKKW TSQQVGTWLK KHNLNGNAKL SKLSGREIVF
LRNLREEAPE FFYHTVEGKL GVTQLGAMVD FTEAIHDLTV
//
