ID V4B245_LOTGI Unreviewed; 432 AA.
AC V4B245;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Flotillin-1 {ECO:0000256|ARBA:ARBA00026228};
GN ORFNames=LOTGIDRAFT_200105 {ECO:0000313|EMBL:ESP01701.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP01701.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP01701.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000256|ARBA:ARBA00025336}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Membrane,
CC caveola {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004543}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR EMBL; KB200406; ESP01701.1; -; Genomic_DNA.
DR RefSeq; XP_009047591.1; XM_009049343.1.
DR AlphaFoldDB; V4B245; -.
DR STRING; 225164.V4B245; -.
DR EnsemblMetazoa; LotgiT200105; LotgiP200105; LotgiG200105.
DR GeneID; 20245384; -.
DR KEGG; lgi:LOTGIDRAFT_200105; -.
DR CTD; 20245384; -.
DR HOGENOM; CLU_038134_1_0_1; -.
DR OMA; ERQYDSE; -.
DR OrthoDB; 5486670at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR031905; Flotillin_C.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF47; FLOTILLIN-1; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF15975; Flot; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 85..271
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 432 AA; 48090 MW; 4FC327D9E4950919 CRC64;
MGFETCGPNE VMVLSGCCHD RSVFIPGGRV FVWPMIQRLQ RMSLNTLTLT IESPNVYTKE
GVAISVTGIA QVRIQGSNDE MLRAACELFL GKTEHEIQTI AKETLEGHQR AMMGNMTVEE
IYKDRKKFSK AVFEVASSDL INMGITVVSY TLKDIRDEET VFKGYLQALG QARTAQVKRD
ARIGEAEATK ESGIKEAVAE EKRMVARYAN DIDIAMAERD YNLKKAAYDQ EVQTKKASAE
LAYGLQAAKT KQKIREEQMQ VTVIERAQMI QVQDQEITRR ERELEATIRK PAEAEKYRME
KIAEANRAKI VMEAQAEAEA VQLKGEAEAF AIEAKAKAEA EQMAKKADAW KDYQDAAMVD
MVLETLPKVA AEIAGPLTNT KKITMVSSGK GDVGAMKITN EVMGIMEKLP SVVENLTGIN
IQKSMKISQR RG
//
