ID   V4B2P0_LOTGI            Unreviewed;      1085 AA.
AC   V4B2P0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN   ORFNames=LOTGIDRAFT_229803 {ECO:0000313|EMBL:ESO82779.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO82779.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO82779.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KB203854; ESO82779.1; -; Genomic_DNA.
DR   RefSeq; XP_009066572.1; XM_009068324.1.
DR   AlphaFoldDB; V4B2P0; -.
DR   STRING; 225164.V4B2P0; -.
DR   EnsemblMetazoa; LotgiT229803; LotgiP229803; LotgiG229803.
DR   GeneID; 20248109; -.
DR   KEGG; lgi:LOTGIDRAFT_229803; -.
DR   CTD; 20248109; -.
DR   HOGENOM; CLU_003794_1_2_1; -.
DR   OMA; ANACGCV; -.
DR   OrthoDB; 22606at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          23..91
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          751..788
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          897..930
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   1085 AA;  121090 MW;  AA91935938235080 CRC64;
     MAVVVEEILA KLLQPNNEVI QEATKQLKEA FKDPGILSAL CHILGSSTNS QIRQYSAVLI
     RRKIQKSRHW NALPNETKES IRRNILQLLV QEPDKNVKTA IGTIIGTIAR HDLPTNKWPA
     LFEFVTVQVK SEDVTKREVG MFILYTLSSD AGEQLKPHLV SVMQILVEAI KDNQSKMVPY
     YAIRTMSELV FLVGMEESLQ FVKKYIQQNI PQILLVIQEL IKVDEEEACE CMELFDELLE
     SEVGVLVPHV KTVVDFCLQI AAQPTLGDAI RVKAMSFIAS LTRLKKNSIL KHKLVDPILE
     VLFPILCANE EEDDEEDVEE IESHTPVQYI PQVFDTMSLH LPPKKFIPNL MPLIEKALAS
     ENPYHRKAGY ISMAVIVEGC ADYIMNKHLK AVLHCVCKGL NDPDNNVRNS ALFALGQFSE
     HLQPDITKYA SELLPLLFQY LGQASQNPES NPRGLTKVYY ALEVFCENLE KKILPYLPPL
     MEHLLAVLKC DHIRSKELAI SAIGATATAA KEEMKPYFNE IIEQLKSYLV TGNTEDMKKL
     QLQTIDTLGI LARNCGPDIF LPLSKECLQL GMNLLESAED PDLKRCVYSL FAAISNLLKS
     DMGDYLEKMV HAMLCSIKSK EGETLHYKEE SDAIGVFNED DLIDEEDIGD EDSEEDDDEH
     KIEGVSVENA YLDEKEDACC SLGEIAINVG APFIPYLEPC YTEVLVLLEY PAENIKKVSI
     ATLSQFCCCV HKVCLDSGMD QTALKNMLNT IIPMYLEIIK TDKERTVVMS AVDSLAEILT
     KIGRPALEIT GATNPILSAM KAIFTHKVAC QDDEDEDDDQ QAEFDAMLIE SAGDVLPTMA
     KLVGGPDFLP FFQSFLTDLL KRLKVTSSVP EKSFAVGTLA EVIQACGDVS AAFVDTLYPL
     FMRLINDEDE EVRSNAVFAI GVLAQYGGQK LHGNFPVILK SLFDIVSKEE EENPRVLDNV
     CAAICRLIMT NSSAIPFDKV IPAIVSFLPL KEDYEENHTV YHCLIELFIA GNPHVLQCTP
     QLLSSIASVI DTDQVKPETQ IILVQFAKHI NDKFPDEFQK VKATLPNDLG GKLDSCLLMV
     NGGGH
//