ID V4B3F8_LOTGI Unreviewed; 208 AA.
AC V4B3F8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Deoxynucleoside kinase domain-containing protein {ECO:0000259|Pfam:PF01712};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_109002 {ECO:0000313|EMBL:ESO82884.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO82884.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO82884.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
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DR EMBL; KB203854; ESO82884.1; -; Genomic_DNA.
DR RefSeq; XP_009066674.1; XM_009068426.1.
DR AlphaFoldDB; V4B3F8; -.
DR STRING; 225164.V4B3F8; -.
DR EnsemblMetazoa; LotgiT109002; LotgiP109002; LotgiG109002.
DR GeneID; 20230416; -.
DR KEGG; lgi:LOTGIDRAFT_109002; -.
DR CTD; 20230416; -.
DR HOGENOM; CLU_030466_1_0_1; -.
DR OMA; CVARDEM; -.
DR OrthoDB; 5393913at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..181
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 81
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 5..13
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 140..144
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESO82884.1"
SQ SEQUENCE 208 AA; 24915 MW; AFF9674F38C1BA48 CRC64;
ICVEGNIGSG KTTLLEYFSK LPNIEVTKEP VDKWRNIKGL NALELMYEDP SRWGLTFQTY
VQLTMLEIHT QPQEKRIKMM ERSIYSAKYC FVENLYKGGK MPEIEYIVLT EWFDFLVRTR
DLNVDIIVYL QTKPETVYER IKERCRSEES SIPLEYLQML HNLHEEWLIN KLFPCPQVVV
SYYIIFIYNN SQLEFLDNKT LWILVKFE
//
