ID   V4B9V0_LOTGI            Unreviewed;      1110 AA.
AC   V4B9V0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Ankyrin repeat and fibronectin type-III domain-containing protein 1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_235745 {ECO:0000313|EMBL:ESO85784.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO85784.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO85784.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
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DR   EMBL; KB203251; ESO85784.1; -; Genomic_DNA.
DR   RefSeq; XP_009063515.1; XM_009065267.1.
DR   AlphaFoldDB; V4B9V0; -.
DR   STRING; 225164.V4B9V0; -.
DR   EnsemblMetazoa; LotgiT235745; LotgiP235745; LotgiG235745.
DR   GeneID; 20249949; -.
DR   KEGG; lgi:LOTGIDRAFT_235745; -.
DR   CTD; 20249949; -.
DR   HOGENOM; CLU_268761_0_0_1; -.
DR   OMA; CPPMFAS; -.
DR   OrthoDB; 5477417at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd17117; RA_ANKFN1_like; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR039269; ANKFN1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR21437; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR21437:SF1; WIDE AWAKE; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00041; fn3; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50200; RA; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT   REPEAT          243..275
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          349..445
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          996..1097
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          145..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          972..993
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          274..301
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        145..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        975..993
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1110 AA;  125194 MW;  95BF89AEC05F4CFB CRC64;
     MSSFKVPEIT KKMSLSTKLV NICKKTAPFG KSKRYVICPT PPKKKNGSAW NVDESSTVLT
     EDNGPCIKPE DIDIKCNPQF YYTTPPTANM VKGPESDKRV EGGRSLYRIS RHLSREKHRT
     NTSRQRSVSL DWGDARTVKL YNSNEDTMEE MPSLTASPSA PAHLSKSGIS PTPGKNRTFA
     VTPRKNRSSD PEISPHKIDK RRFDKRPSYD NNALFCAVEN QDLDLVKEIL DANTVDINSV
     NCENLSPLDI AVMTNNIPMA KMLLYKGAKE NTQFEKSGSR LKRLESLVRK AERKVIDLTA
     IVLNGTSGNS GISPTQQKEK EKELNHWEFR HRLLKRMKAG YDHAKPPDCP TNVTLSVNSS
     SSLLVRISEP LNHNGAVVTK YKVEWSCYEN FKPLVNEGIA DNIQALEYEI TGLEKGVRYY
     VKVSAWNMKG YGPSTTSNPL YSVPSCWRDV DRCSARLSGK VRSLQKLFDE VRQSRPEHAS
     TIRDSVCREM ESPLLKKRIS IKSLFVSAPK FQKSLKRGVY MACVLYNEDK ILLTSEDQIP
     IVEVDENFSG TSIQSDLYWM MKIACTWDDV KSLRQDMVKS SSAGTVHFRS KLLQAASYLQ
     NSLGIQDVGQ FFYLPLKDSN GSIVLTIVNH VKDTKLVGLG SSKWVSTDKI SRRQSLAGLD
     NTDALCQLVS SIPEMRLYHQ VSTISLPKGL YLGYLKLHSS VENIRVLVPQ TSPSSLPHSK
     IRDCPNVSRE EWEWLHQLNS VDDMTNETTT QHYQFQQAIT KSCKRLFSSL GIDEDLAASH
     RLYKYEVIEF SPNVSFILIL PSVEDVCIIP GQTDTFTQNN HFTFLPVQVF ELIHMMTYQK
     EFIAHYSRLS SILEMDVNLA QQAQREAFSN EELTVAKDQV EKSSSHQVEL ESMWKDVRWV
     KDIISYSRDR HAKSGIPVSL FFDSDNGNCS PDTQHRQTKI LDNNNSSTSI SVSCNSNEIS
     VGKDNRKIAK FYDPNEESSA TSDSVFSDDS SSTMSQSGVL RVYAAYETGF SKTVSVKLHV
     MTQTTAREVI NMVVSQLNKA LVSRGKTGPI YEEDQFDDFC LVAVIGVRER VLRDDYQPLQ
     LQNPWTKGRL YVRMRSNVLA AIEQGQATAV
//