ID V4BDG3_LOTGI Unreviewed; 802 AA.
AC V4BDG3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=LOTGIDRAFT_167072 {ECO:0000313|EMBL:ESO86549.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86549.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO86549.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KB203049; ESO86549.1; -; Genomic_DNA.
DR RefSeq; XP_009062784.1; XM_009064536.1.
DR AlphaFoldDB; V4BDG3; -.
DR STRING; 225164.V4BDG3; -.
DR EnsemblMetazoa; LotgiT167072; LotgiP167072; LotgiG167072.
DR GeneID; 20240521; -.
DR KEGG; lgi:LOTGIDRAFT_167072; -.
DR CTD; 20240521; -.
DR HOGENOM; CLU_006000_1_1_1; -.
DR OMA; TENEMIC; -.
DR OrthoDB; 2968132at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..802
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004717445"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 651..787
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 802 AA; 92539 MW; FA0AD75648955152 CRC64;
MMNMPQNIVI WMLGFILLVE GQNITTDVPK QELYCPQSCT CGEGSNLPRI YQPFADIRHI
YCVWTNDSLN FTEEITMATE SDQSTAYDIH IKCYGDTDIV WTSSDFLQKT FAVRMFNCNI
INDGLILFPT DSITKIFVLD TLRPADVDKF QFQGFKSATV FQISYSNLNR IPNLPFMPSL
LVLTLEGNNI TDLSCDLFYK KICLMCIVEL SSNSLTSIPN CPSFSSTRFG SPTYNFGNNK
LSDISYIGNL DMTRVDLSYN QISHLPNFTK FNLFNLTVSH NSIKEIKRNS FPSNIMLRYL
DLSYNQIETI ETAAFSNLLN LKELSLNGNN LIIFDSRHLS PTYYVIDVDL RSNQLEYPPF
QDGRLPEPPS YLKIRAAENP YICDCTTNEL MTQQSVQQIF SDTNLMKCQR PTRLQNQSVV
SLNLTDSCPI VRKCPVSCVC DYNRISDITS IVCSNRTLSA LPLDLPGGKL NLNLTSNMIN
ILDKRDYFPR IVELDLSYNE ISNISSTGLT LLSNILTLDL TNNNITSLPR SITQVPFSST
TQIYVSSNPW LCSCDLLWFA QWLGEKNSSI SDKDQLRCNF LSINVIDITE DNFKCNVQLK
TYLYYLITIL LLIIIFFVFL IIKCRYNAKV LLYTRLRIQY FAPPIVSEKL KENDVFIVYD
DEDITWMKYV LLKRLEDIEK PGYKTVIKDR DFLPGLDENE NVNDAISNSY CTLFIFSDNF
LQNEWCLYNF HCAYEHMLKE KDIKIVIILK DKIDVDKLND DLKAYFKTHT YLEFNDTIFW
DKLLYVLPKN SHIIPHENYI IV
//
