ID   V4BDS2_LOTGI            Unreviewed;       856 AA.
AC   V4BDS2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Prominin-like protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LOTGIDRAFT_156479 {ECO:0000313|EMBL:ESP03882.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03882.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESP03882.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB199905; ESP03882.1; -; Genomic_DNA.
DR   RefSeq; XP_009045364.1; XM_009047116.1.
DR   AlphaFoldDB; V4BDS2; -.
DR   EnsemblMetazoa; LotgiT156479; LotgiP156479; LotgiG156479.
DR   GeneID; 20237013; -.
DR   KEGG; lgi:LOTGIDRAFT_156479; -.
DR   CTD; 20237013; -.
DR   HOGENOM; CLU_008293_1_1_1; -.
DR   OMA; IVCAYMV; -.
DR   OrthoDB; 3538424at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF1; PROMININ-LIKE PROTEIN; 1.
DR   Pfam; PF05478; Prominin; 1.
DR   SUPFAM; SSF58113; Apolipoprotein A-I; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        716..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          771..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  95678 MW;  276F85A0F929430B CRC64;
     MAQKYLFGWT IPRPDNEDLT AIAQGHFDFA EFNSRWQEVS SYFLGYTLCL AVGVLFAIIM
     PIVGCCFCCC RCCGRCGGKR KLHDPKRAKC KRTSYCTVLL IINTVCLAGV ICAFVTNDIL
     HQKLDNKDKM GPLGNVDKAV ASLDNYVNNT VKFLEKNILK TYEAATEEIT ISINESAITA
     VKKVLDIVNA SVFIDQTKDL AKKTDIVLDD LVNIRDTLKE LKTNGDTLST NLTQLKNEID
     QFCQPPNNGK CTGLDTDKYK TEADFSKLSE LSTEIDNVKD SLNITQYINQ VEGKIDQVKS
     NVTDKISDSI IKATNTMRDV RKDVTNGIDL CKGKIQDATK PVFDFQGSLE SEQSEISKYG
     NYVWYAGLGI SCLLLLIVLF YYLGVLFGMC GERPGRGAAC CNTGVGGNFL MAGVAFSFVF
     SWILMIICLI LFLAGGFAYT EACRYFVTHE PADLQPFENL VFQNLDFTKN LFNDSNAKFS
     IVQTLKNCEE NQAIYTALQL DSFLNINNYL NISSLYKQID NIAKSNVDFN NITILIPELR
     QQIEEFGNAG LDKIDYDSFE AEINKNLTAI DLIELAKKLE NKAASETGQF KQQLEEFAAK
     LRRMDKELVT PMKKDVTNLK GNLTHLKENS NVKPETEALV KGLESAEKKF NSEGVTEVNT
     MLSEVVNNIK NTLGNKTTDI KTMIKKDAGK CRPVYDSIYL MTDAFCVVVL YPMNGFWFSM
     GWCLFFFIPS IIFAVKLSTL YHREEEYVEE KGFDDPNFSM YAGPNPDTIP LTSSTGPQHG
     NGYGAHNTGY RDDGYRGKSN GYPTHAEGPP GYNDGYRGRP APRLEANDTS IGDGVPYYYY
     PPPNETPLPA YSPQKF
//