ID V4CIB4_LOTGI Unreviewed; 395 AA.
AC V4CIB4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Alpha-carbonic anhydrase domain-containing protein {ECO:0000259|PROSITE:PS51144};
GN ORFNames=LOTGIDRAFT_238082 {ECO:0000313|EMBL:ESP01890.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP01890.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP01890.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718}.
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DR EMBL; KB200330; ESP01890.1; -; Genomic_DNA.
DR RefSeq; XP_009047380.1; XM_009049132.1.
DR AlphaFoldDB; V4CIB4; -.
DR SMR; V4CIB4; -.
DR STRING; 225164.V4CIB4; -.
DR EnsemblMetazoa; LotgiT238082; LotgiP238082; LotgiG238082.
DR GeneID; 20250653; -.
DR KEGG; lgi:LOTGIDRAFT_238082; -.
DR CTD; 20250653; -.
DR HOGENOM; CLU_698865_0_0_1; -.
DR OrthoDB; 2967272at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00326; alpha_CA; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 2.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF265; CARBONIC ANHYDRASE; 1.
DR Pfam; PF00194; Carb_anhydrase; 2.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 42..365
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 395 AA; 44718 MW; B542C7D9A22AC7BC CRC64;
MKLQGAGCVV AAVLGALFIV NVESHFHKPE LQLCKAFGEP CISYDVRSTI GPRCWFKLEF
PREKCCNENG KRQSPIDIPD VKSIYKVPQK LRYSSRKFVG HLENTGIQPA FKRKVGADKV
YLEGIGSPVG KRYFIENVHF HVGVRHKERQ TENTLNGRSF DGEAHIVHIR EDFGDLKEAA
NHPQGLLVIS IFLSTSKGER RRDGFDDLIE MIQDVQEFEE EDGPCANVKI PDIFKFKQLI
PFHPVWPICK KTFPVADDSD NSGSGVVCNF YLPNGLCGEK KESKINPNEL LADDPEYYVF
NGGLTTPPCS ESVLWLVAKQ PRKVSVFYPY VVRNMETQRE GEIIGDFGNL RPLQDLNDRP
VFLVRFRLKR NWEHGDTAAN DNDAMDSPFS VLGIN
//
