ID V4HDW8_9EURY Unreviewed; 764 AA.
AC V4HDW8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Peptidase S8/S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:ESP88850.1};
GN ORFNames=K933_07132 {ECO:0000313|EMBL:ESP88850.1};
OS Candidatus Halobonum tyrrellensis G22.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Halobonum.
OX NCBI_TaxID=1324957 {ECO:0000313|EMBL:ESP88850.1, ECO:0000313|Proteomes:UP000017840};
RN [1] {ECO:0000313|EMBL:ESP88850.1, ECO:0000313|Proteomes:UP000017840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G22 {ECO:0000313|EMBL:ESP88850.1,
RC ECO:0000313|Proteomes:UP000017840};
RX PubMed=24336364;
RA Ugalde J.A., Narasingarao P., Kuo S., Podell S., Allen E.E.;
RT "Draft Genome Sequence of 'Candidatus Halobonum tyrrellensis' Strain G22,
RT Isolated from the Hypersaline Waters of Lake Tyrrell, Australia.";
RL Genome Announc. 1:e01001-13(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESP88850.1}.
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DR EMBL; ASGZ01000023; ESP88850.1; -; Genomic_DNA.
DR RefSeq; WP_023394013.1; NZ_ASGZ01000023.1.
DR AlphaFoldDB; V4HDW8; -.
DR STRING; 1324957.K933_07132; -.
DR PATRIC; fig|1324957.4.peg.1441; -.
DR eggNOG; arCOG06823; Archaea.
DR eggNOG; arCOG07554; Archaea.
DR OrthoDB; 341609at2157; -.
DR Proteomes; UP000017840; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR NCBIfam; NF012200; choice_anch_D; 2.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000017840};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 201..327
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 442..571
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 607..686
FT /note="Abnormal spindle-like microcephaly-associated
FT protein ASH"
FT /evidence="ECO:0000259|Pfam:PF15780"
FT REGION 35..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 210
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 243
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 523
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 764 AA; 75858 MW; 5EE63E60880A825B CRC64;
MSRRTRAAAV VFALLMVAAP AAGAIDPAGR LGAPAGPTDR GATAGAVTAP SVADGTTNAT
NATNSTEADA DATRTATADG SGTDDAARKL SAALRGDRGA TADRSVAAAS VDDPAPVTVV
VLTDPGAAES VAAAVRALDG TVELVHGDAV QATLPRAALG ALAERSDVSY VRKPRRPEPT
VVSEGVGSIN ATALHDRGVT GENVTVAVVD VGGFNLSNPE LDGVVAHRNY HEGGIGNGTV
GAHGTATAAL VSDAAPGANV VAVRVGTYLQ AQAAVEWLRE ETDVDAVSMS LGWKDVGPLD
GTAPLSTEIQ RSVDAGTPYF VAAGNAGGGN HWDGQWSDPD GDGWLNFAGD DELMTVETVS
PGSSMLFALQ WDDWPDSDQD YALYLYQYES DFDDGDPDGG MAYEVVDTAQ TGSQEPLERF
EMSGAYGRYY VAVRSQDADN SSYFTAFAGD AQRLTPSTSA RSVTEPGVAP AATTVGAVDA
ATGELEPFSS RGPTVDGRRK PDLVGPDNVS TGAYGGSSFY GTSAAAPHTA GAAALLLGVD
PDLSPAEVET TLTETASPVG GSEPNSNAGA GLVDAGAAVA SVGGGDTGSG AVDARPEAGA
PANASAGSVT VGGSTTLNVT VENDGNAPLS VTDTEIAGPN ASAFTVTNAP ATVAPGGNGT
VTVEFAPTSV GSQRATLSVA HNASGSPLTV GLSGTGVGTA SVRVPATRAF GNVSVGETAT
RNVSVENTGT APLSVAEVGV AGADAEAFTV TNAPDTVAPA RTGP
//
