GenomeNet

Database: UniProt
Entry: V4I6B6_9ACTN
LinkDB: V4I6B6_9ACTN
Original site: V4I6B6_9ACTN 
ID   V4I6B6_9ACTN            Unreviewed;       696 AA.
AC   V4I6B6;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   20-JUN-2018, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ESQ05322.1};
GN   ORFNames=B590_15248 {ECO:0000313|EMBL:ESQ05322.1};
OS   Streptomyces sp. PVA 94-07.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1223307 {ECO:0000313|EMBL:ESQ05322.1, ECO:0000313|Proteomes:UP000017765};
RN   [1] {ECO:0000313|EMBL:ESQ05322.1, ECO:0000313|Proteomes:UP000017765}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PVA 94-07 {ECO:0000313|EMBL:ESQ05322.1,
RC   ECO:0000313|Proteomes:UP000017765};
RA   Ian E., Sekurova O.N., Malko D.B., Ruckert C., Borisova M.E.,
RA   Albersmeier A., Kalinowski J., Gelfand M.S., Zotchev S.B.;
RT   "Draft sequence of Streptomyces sp. PVA 94-07, a marine actinomycete
RT   isolated from the sponge Phakellia ventilabrum collected in the
RT   Trondheim fjord (Norway).";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESQ05322.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ASHE01000008; ESQ05322.1; -; Genomic_DNA.
DR   RefSeq; WP_023418317.1; NZ_CM002273.1.
DR   EnsemblBacteria; ESQ05322; ESQ05322; B590_15248.
DR   PATRIC; fig|1223307.4.peg.3193; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017765; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017765};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017765}.
FT   DOMAIN      389    517       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      603    672       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     397    404       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      672    692       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   696 AA;  77288 MW;  09DFBC89F7D080FB CRC64;
     MADVPADLAA VWPRVLEHLL GDGRGQGVEA KDEQWVRRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPVV SETLSRECGR PIRIAITVDP TMGDPAPPQR YPEPPSRPAQ ERGYGYPPYG
     AAVERRGEEP EPEEQQPPRE EERRPGAFPF LQDHGRYEYE QEPLGGDRYE AGRYDQDRHA
     GEPYHQEQGY PQEQYGDGYG QDRYEGQRGQ EQGGGGELRD EERRGRDGLP QARPAYPEFQ
     RPRPEPGAWP RVQDDYWQQP RLGYPERDSY TGPSHGGNGQ HDFRPSGSER GDYGRREQLD
     DGHDPRGPRE GRGAHGGHGV HSGGPVGSAL PASSGAPGPL AAQPAPATGP GEPTARLNPK
     YLFDTFVIGA SNRFAHAAAV AVAEAPAKAY NPLFVYGESG LGKTHLLHAI GHYARSLYPG
     TRVRYVSSEE FTNEFINSIR DGKGDSFRKR YREMDILLVD DIQFLADKES TQEEFFHTFN
     TLHNANKQIV LSSDRPPKQL VTLEDRLRNR FEWGLITDVQ PPELETRIAI LRKKAVQEQL
     NAPPEVLEFI ASRISRNIRE LEGALIRVTA FASLNRQPVD LGLTEIVLKD LIPGGEDAAP
     EITATAIMAA TADYFGLTVE DLCGSSRSRV LVTARQIAMY LCRELTDLSL PKIGAQFGGR
     DHTTVMHADR KIRALMAERR SIYNQVTELT NRIKNG
//
DBGET integrated database retrieval system