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Database: UniProt
Entry: V4K0W6_EUTSA
LinkDB: V4K0W6_EUTSA
Original site: V4K0W6_EUTSA 
ID   V4K0W6_EUTSA            Unreviewed;      1059 AA.
AC   V4K0W6;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-JUN-2019, entry version 28.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=EUTSA_v10003565mg {ECO:0000313|EMBL:ESQ31505.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae;
OC   Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ31505.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ31505.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J.,
RA   Jenkins J., Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KI517748; ESQ31505.1; -; Genomic_DNA.
DR   RefSeq; XP_006394219.1; XM_006394157.1.
DR   STRING; 72664.XP_006394219.1; -.
DR   KEGG; eus:EUTSA_v10003565mg; -.
DR   KO; K02327; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 2.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030689};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      125    468       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      532    777       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      781    933       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      971   1040       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     39       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V4K0W6}.
SQ   SEQUENCE   1059 AA;  119217 MW;  41D33D13854B79C9 CRC64;
     MNRAGNSKKR PPPSNTPPAG KHRATGNPTP SPPVGTLEDE FVDEDVFMDE GDEESLILRD
     MEEREAVSAR SSTWARPPLS PAYLSNSQNI IFQQLEIDYV IRESHKELLP GSSGQAAVIR
     IFGVTREGHS VCCYVHGFEP YFYIACPPGM GPDDISHFHQ ILEGRMRESN KNASVPKFVR
     HIEMVQKRSI MYYQQQKSQT FLKITVALPT MVASCRGILD RGIHIDGLGM KSFQTYESNI
     VFALRFMVDR DIVGGNWIEV PTGKYKKDAR TLSYCQLEFH CLYSDLISHA AEGEYSKMAP
     FRVLSFDIEC AGRKGHFPEA KHDPVIQIAN LVTLQGEDQP FVRNVMTLKS CAPIVGVDVM
     SFETEREVLL AWRDFIRDVD PDIIIGYNIC KFDLPYLIER AATLGIDEFP LLGRVKNSRV
     RVRDSTFSSR QQGTRESKET TIEGRFQFDL FQAILRDYKL SSYSLNSVSA HFLSEQKEDV
     HHSIITDLQN GNAETRRRLA VYCLKDAYLP QRLLDKLMYI YNYVEMARVT GVPISFLLAR
     GQSIKVLSQL LRKSKQKNLV LPNAKQSGSE QGTYEGATVL EAKTGFYEKP IATLDFASLY
     PSIMMAYNLC YCTLVTPEDV RKLNLSPEQI NKTPSGETFV KQSLQKGILP EILEELIAAR
     KRAKADLKEA KDPLEKAVLD GRQLALKISA NSVYGFTGAT IGQLPCLEIS SSVTSYGRQM
     IEQTKKFVED KFTTLGGYEY NAEVIYGDTD SVMVQFGVSD VEAAMNLGRE AAEYISGTFI
     KFDKMDTKGI ETVRRDNCLL VKNLVTESLH KILIDRDVPG AAEYVKNTIS DLLMNRIDLS
     LLVITKGLTK TGDDYEVKSA HGELAERMRK RDAATAPNVG DRVPYVIIKA AKGAKAYERS
     EDPIYVLQNN IPIDPNYYLE NQISKPLLRI FEPVLKNASK ELLHGSHTRS ISITTPSNSG
     IMKFAKKQLS CVGCKVPISN GTLCQRCKGR EAELYCKNVS QVSDLEEVFG RLWTQCQECQ
     GSLHQDVLCT SRDCPIFYRR MKAQKDMAVA KQQLDRWSF
//
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