ID V4K3E0_EUTSA Unreviewed; 770 AA.
AC V4K3E0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=EUTSA_v10003683mg {ECO:0000313|EMBL:ESQ31980.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ31980.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ31980.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
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DR EMBL; KI517748; ESQ31980.1; -; Genomic_DNA.
DR RefSeq; XP_006394694.1; XM_006394632.1.
DR AlphaFoldDB; V4K3E0; -.
DR STRING; 72664.V4K3E0; -.
DR EnsemblPlants; ESQ31980; ESQ31980; EUTSA_v10003683mg.
DR GeneID; 18012348; -.
DR Gramene; ESQ31980; ESQ31980; EUTSA_v10003683mg.
DR KEGG; eus:EUTSA_v10003683mg; -.
DR eggNOG; KOG1027; Eukaryota.
DR OMA; RRWNKEP; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:EnsemblPlants.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:EnsemblPlants.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0034263; P:positive regulation of autophagy in response to ER overload; IEA:EnsemblPlants.
DR GO; GO:0000394; P:RNA splicing, via endonucleolytic cleavage and ligation; IEA:EnsemblPlants.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF27; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE1B; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 350..633
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 636..767
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 528..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 86913 MW; CA14C8E401629B7A CRC64;
MDCDKDWNLY NSSMREGKRI NEIVDASNFI GSLPYSLTDR IVLGKKDTSV FLLDGKTGNL
VKRYRVDDLY SNSVVQDAKE KAIVLSEEAP ILLGSGFKEP EDRPELVYIE RKDFKLQCVS
KFGDVLWSLS YAEMEAKLQH HESAQLMGGL SSSAGIPIRT TNTPVLRFRY KFEQMFPRLG
FQDGALYLTF QDRKPNQLAP GNGNPLALPS NNEAEEVLSL PLPETVISQI TDISDGSSTQ
TGVAKKISDL IVLLIGFCVT VLSLCGLVFR RIRQSKWIKE PCVSEVPIVI PKKKKSKKNG
TTKAIHKKEN GYISGGNKDL SFEENEKKLV TTFPGLNNSP LEGYRVGKLF VSNKEIAKGS
NGTVVLEGSY EGRLVAVKRL VQTHHDVAQK EILNLMASDK HPNIVRWYAV DQDEHFIYIS
LERCACSLND LIYASCGLLE NPVASSSIHS IQINPILDNG KGVELWKENG HPSPVLLKLM
RDIVAGLVHL HDIGIVHRDL KPQNVLIVKN SSVCAKLSDM GISKRLPADT SALTRNSTGS
GSSGWQAPEQ LRNERQTRAV DLFSLGCVLF FCMTAGKHPY GDNFERDINI LNDRKDLFLI
ESLPEAVHLL SGLLHPDPNL RPRAQEVLHH PLFWNSDMRL SFLRDASDRV ELENREEGSQ
LLAALESTAT VTLNGRWDEK LDSIFLDNIG RYRRYKFDSI RDLLRVIRNK LNHYRELPRE
LQELLGSVPE GFDRYFSSRF PKLLIQVYTV LFEYCNNEEF FFKYSKTTVF
//
