ID V4K3Z6_EUTSA Unreviewed; 853 AA.
AC V4K3Z6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
GN ORFNames=EUTSA_v10003644mg {ECO:0000313|EMBL:ESQ32235.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ32235.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ32235.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR EMBL; KI517748; ESQ32235.1; -; Genomic_DNA.
DR RefSeq; XP_006394949.1; XM_006394887.1.
DR AlphaFoldDB; V4K3Z6; -.
DR STRING; 72664.V4K3Z6; -.
DR EnsemblPlants; ESQ32235; ESQ32235; EUTSA_v10003644mg.
DR GeneID; 18011755; -.
DR Gramene; ESQ32235; ESQ32235; EUTSA_v10003644mg.
DR KEGG; eus:EUTSA_v10003644mg; -.
DR eggNOG; KOG0351; Eukaryota.
DR OMA; HCNALEV; -.
DR OrthoDB; 1207998at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:EnsemblPlants.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:EnsemblPlants.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF69; ATP-DEPENDENT DNA HELICASE Q-LIKE SIM; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT DOMAIN 3..46
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 169..345
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 483..642
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 54..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 97126 MW; BF9AC9FF6720A739 CRC64;
MDKLDSSSDE VVMKLVEMGF EKLVAMEAVK AVGNSCDDAV EYVLKGHHKS GTSKINKALG
RRAMPSSFSS GPMRQSSLLD HFKSVDRNSK KGHSFDATVA DSQLETLSDP SEELRKSSPP
VFFESSCFPD TQLSNGCSEA SSTWEKRVNS ILRIRFGISS LKSFQREALS TWFAHKDCLV
LAATGSGKSL CFQIPALLTG KVVVVISPLI SLMHDQCLKL SMHKISACFL GSGQLDNRIE
QKAMQGMYQI IYVCPETVVR LIKPLQRLAQ THGIALFAID EAHCVSKWGH DFRPQYRRLS
VLRENFCASK LEFLEYDVPI MALTATATSH VQEDILESLH LSKETKTVLT SFFRPNLQFS
VKHSRTKSSA SYAKDFQNLI DFYSEKRKAT GKKLAVISRE SEEQTDSGYH DAENIHETDS
DDDEEDPENS LAKPNSSNGK EMSEDYLEDE TNISQRVDDW DVACGEFCEM SVLSGKQIPD
ASGHENSLQE KDFEGPTIIY VPTRKESVNI AKYLYGVGLK AAAYNASLPK KHLRQVHQEF
HENKLQVVVA TIAFGMGIDK KNVRKIIHYG WPQSLEAYYQ EAGRAGRDGE LAECVLYANL
SRVPTLLPSH RSKEQTEQAY KMLSDCFRYG MNTSQCRAKI LVEYFGEDFS SKKCNLCDVC
TEGPPEQVNV REEANLLFQV ITAFHVENSS EHTSYEDYGL GNSEQKKLSH KPNLLFFISR
IREQSQKFME IDRLWWKGLA RIMEAEGYIK EMDNKGRRVE IAYIEPTEKG KKQLDFQEDK
PLYVYPEADM LVSLRQRRTY SGFSDWGKGW ADPEIRRQRL EAMKRPRERR PRRERSQQRP
LKLQKKIPWR SKE
//
