ID V4KKH4_EUTSA Unreviewed; 425 AA.
AC V4KKH4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Cysteine proteinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=EUTSA_v10028681mg {ECO:0000313|EMBL:ESQ38375.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ38375.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ38375.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KI517537; ESQ38375.1; -; Genomic_DNA.
DR RefSeq; XP_006396922.1; XM_006396859.1.
DR AlphaFoldDB; V4KKH4; -.
DR EnsemblPlants; ESQ38375; ESQ38375; EUTSA_v10028681mg.
DR Gramene; ESQ38375; ESQ38375; EUTSA_v10028681mg.
DR KEGG; eus:EUTSA_v10028681mg; -.
DR eggNOG; KOG1543; Eukaryota.
DR OMA; HEYTELC; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF1021; CYSTEINE PROTEASE RDL4-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT DOMAIN 110..166
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 198..413
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 425 AA; 46928 MW; 2F8A4D5F9C99FEF3 CRC64;
MIHAYNMRLI QIIQHKNLLS SFCFFSTYKK KQTQTKVSLV LNPKKKMGSA KSALLILLLA
MVIASCATAM DMSVVTYDDN HHVTAGPGHH VTAGPGRRNG VFDVEASLIF ESWIVKHGKV
YDSVAEKERR LTIFKDNLRF ITNRNSENLG YRLGLNRFAD LSLHEYKEIC HGADPKPPRN
HVFMSSSDRY KTSAGDVLPK SVDWRNEGAV TEVKDQGHCR SCWAFSTVGA VEGLNKIVTG
ELVTLSEQDL INCNKENNGC GGGKVETAYE FIVSNGGLGT DNDYPYKAVN GACDGRLKEN
IKNVMIDGYE NLPANDELAL MKAVAHQPVT AVIDSSSREF QLYESGVFDG RCGTNLNHGV
VVVGYGTENG RNYWIVRNSW GNTWGEAGYM KMARNIANPR GLCGIAMRVS YPLKNSFTTG
KSSMA
//
