ID V4KYU0_EUTSA Unreviewed; 738 AA.
AC V4KYU0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EUTSA_v10006912mg {ECO:0000313|EMBL:ESQ36529.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ36529.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ36529.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
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DR EMBL; KI517683; ESQ36529.1; -; Genomic_DNA.
DR RefSeq; XP_006418176.1; XM_006418113.1.
DR AlphaFoldDB; V4KYU0; -.
DR STRING; 72664.V4KYU0; -.
DR EnsemblPlants; ESQ36529; ESQ36529; EUTSA_v10006912mg.
DR GeneID; 18994461; -.
DR Gramene; ESQ36529; ESQ36529; EUTSA_v10006912mg.
DR KEGG; eus:EUTSA_v10006912mg; -.
DR eggNOG; KOG4362; Eukaryota.
DR OMA; NTICAFC; -.
DR OrthoDB; 318045at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProt.
DR GO; GO:0140096; F:catalytic activity, acting on a protein; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd17720; BRCT_Bard1_rpt2; 1.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF9; BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 25..63
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 356..476
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 516..602
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 623..738
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 99..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 81612 MW; 6EC7E8161DD2BFD1 CRC64;
MAGFTNMLMN PWVLHLQKLG LELKCPLCLK LLNRPVLLPC DHVFCESCIH KSSQVESSCL
VCKSKYPKKA RRNLHIMESV ISMYKSLNAA VSVHLPQLQN QNDGNYKNDA QNNSSSQKDG
GSEDSEMIDK DVIKRSGGGS NSSSHDGSPL PTSQESNQRP KHQDWSKQQI VDPLPLYEFE
SANDAGNHTP ESHTGPAAKS LSDITVSEKP DKAARRRICG DSLSHDDSPL PKSQESNPNP
KTQDLTERLL MESLRSYDFQ PESDNDPTDH IKAEKRQLSK SHTEQAAKRK RDTTASEAME
NHQKYPKRQK NLMQKAADVD FNDNYTANSD DQLIGKPSKA SNLTPSVISD QPSSNITICG
FCQSDRVSEA TGEMLHYSRG RPVVGDDIFR SNVIHVHSAC IEWAPQVYYE ADTVKNLKAE
LARGMKIKCT KCGLKGAALG CYVKSCRRSY HVPCARGISR CRWDYEDFLL LCPAHSSVKF
PNEKSGHRVS RAEPLPKINP AELCSLEKTP AITKDLVLCG SALSQSDKRL METLAAKLNA
TISRYWNPSV THVIASTDEK GACTRTLKVL MGILNGKWII NAGWIKASLE ASQPVDEEPF
EIHIDTQGCH DGPKTARLRA ATNKPKLFDG LKFYFFGDFC KGYKEDLQNL VKVAGGTILN
TEDELGAESS NNVNDQRSSI VVYNIDPPIG CALGEEVTII WNRANEAEAL SSKTGSRVVG
HTWLLASIAG YKLHPMAS
//
