ID V4L2P6_EUTSA Unreviewed; 763 AA.
AC V4L2P6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125, ECO:0000256|PIRNR:PIRNR028937};
GN ORFNames=EUTSA_v10006882mg {ECO:0000313|EMBL:ESQ36532.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ36532.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ36532.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation. {ECO:0000256|ARBA:ARBA00003842,
CC ECO:0000256|PIRNR:PIRNR028937}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920,
CC ECO:0000256|PIRNR:PIRNR028937};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR028937}.
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|PIRNR:PIRNR028937}.
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DR EMBL; KI517683; ESQ36532.1; -; Genomic_DNA.
DR RefSeq; XP_006418179.1; XM_006418116.1.
DR AlphaFoldDB; V4L2P6; -.
DR STRING; 72664.V4L2P6; -.
DR EnsemblPlants; ESQ36532; ESQ36532; EUTSA_v10006882mg.
DR GeneID; 18994465; -.
DR Gramene; ESQ36532; ESQ36532; EUTSA_v10006882mg.
DR KEGG; eus:EUTSA_v10006882mg; -.
DR eggNOG; ENOG502QSD8; Eukaryota.
DR OMA; VSMSKHW; -.
DR OrthoDB; 654627at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF5; LONG-CHAIN-ALCOHOL OXIDASE FAO1; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR028937-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR028937-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR028937};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR028937};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 297..518
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 614..746
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT ACT_SITE 692
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
FT BINDING 248..263
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-2"
SQ SEQUENCE 763 AA; 84487 MW; 476C69A47DE808BC CRC64;
MVGEKRKRGE KRGNPLLRWS VKQESFTHGF SRSDLQALSA ICEAIMPPVP LLSLDLDMKL
KVLRNDALLS FFKSSSDQSH VRPDEVAEVM ATKAMPVTVK VVRIVLRLLT FRLGTLLLCG
FVCLDKKNWP FLLKFSDISL DKREKVLQKW STQWYNPLVR IAFMMIKAIF LFYYFTWTNE
NSETPAWDAI GYSVNLGENE DMEHRERPLE KGIIETAKED EMSIKQRLIN KGLIVTEDKE
SDSYKIECDA VVVGSGCGGG VAAANLAKSG LRVVILEKGN YFVPRDYSAL EGPSTFELFE
AHSLLMTHDG RFRFMAGSTV GGGSVVNWAA SLKTPDAIIN EWSVDRGIAI FAREEYTAAM
ERVCKRIGVT EKIIKEGFQN QILRKGCEKL GLDVTVVPRN SSEKHYCGSC SFGCRTGDKR
GTDSTWLVDA VNNNAVILTQ CRAEKLILAD NDAQTRKQSG RKKICLGVTA CPSNRTRKKL
QINAKVTVVA CGSLMTPGLL ASSGLRNPNI GRGLHIHPIL MVWGYFPEKN SDFNGAAHEG
EIVTSLHYVF EIDSTTTPNI TLETPAIGPG TFAALIPWVS GSDMKNRLAK YARTSHIFAM
IRDEGVGEVK GGLVKYRLTK ADEENLAIGL KQALRILVAA GAEEVGTYRS DGQRIKCKGI
KEEDLEAFLR TVNVPAGAVS MSKHWTHSFT AHQMGCCRMG ATEKEGAIDG YGESWEAQDL
YVCDASVLPT ALGVNPMITI QSTAYCISNR IAMLMEKKKK KKD
//