ID V4L7T2_EUTSA Unreviewed; 1134 AA.
AC V4L7T2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=EUTSA_v10000021mg {ECO:0000313|EMBL:ESQ46425.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ46425.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ46425.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; KI517426; ESQ46425.1; -; Genomic_DNA.
DR RefSeq; XP_006404972.1; XM_006404909.1.
DR AlphaFoldDB; V4L7T2; -.
DR EnsemblPlants; ESQ46425; ESQ46425; EUTSA_v10000021mg.
DR GeneID; 18022112; -.
DR Gramene; ESQ46425; ESQ46425; EUTSA_v10000021mg.
DR KEGG; eus:EUTSA_v10000021mg; -.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR OMA; MKIYDSC; -.
DR OrthoDB; 645923at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT DOMAIN 5..168
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1134 AA; 128545 MW; BF1F53EA49EE212B CRC64;
MVPSSEHKVY INFRGADLRH GFVSHLIPAL KMNGVGVFVD QMEARGQEIG SLFKRIEESE
IALVIFSERY TESAWCLDEL VKIKETKEEG KLIAIPIFYK VEPSQVRKLM GQFGDNFWRL
CRSSRAGHIM KWKEALESTA STLGFVLSEG SSESRIVTDI VKNVMRIISE QEGEKPSLFP
STAKGKRTEL PTGKEEKLFG MELRMEQLEK KLEFDCNDTR IIGVAGMPGI GKTTLAMKLH
EKWNRKFVRC VPFLDIRKKS EDYGPAGLRK TLLELLLEGK LSDESTHGSV KVELLKTKIF
AVLDDVSDKE QLEFLLGELD WIKKGSKIII TTCDKSLLEG FTNDTYVVPE LNDGEASQLL
RYHAFDGQCS PTSTFLMLSR IFVEYARGHP LILTLLGREI YGKGEAELEM VTEKPNMMVQ
NAWRFFAEQL KLSDKQKDVF LDIVCFFKSE DEYFVRSLLD SGDPDSTDAV SEVKDLVNKF
LITITDGRVE MNVPLHTFSK DQGSPRWLSL SNYEEIISVL TKMEESDVNN VRGIFLDTSN
LTKSMCLDIS TFIDMRNLRY MKIYDSCCLR QCKADCKLHF PDGLEFPLEE IRYLHWVKFP
LEELPPDFRP ENLVDLRLPY SKITRVWEGE KETPRLKWVD LSHSSELLDL SALSMAENLQ
RLNLEGCTSL DELPVEIQNM KSLVFLNLRG CIRLWSLKMN LISLKTLILS DCSNLKDFQL
ISESVEFLHL DGTAIKGLPL AIQNLRRLVM LNLKNCKMLE SLPDCLGDLK SLDKLILSGC
SRLKNLPDVR NSLKHLQILL LDGTGVKEMP SMSCFTGSES PASEDTFLQP LGSHCSAREW
PCGVREVSSL RRLCLSGNDF VTLHPDIGKL YNLKWLDVKY CQRLISVPML PPRLQYFDAH
GCDSLETVAN PVALSVLSDP IHATFNFSNC NKLDQDAKDN IISYTRWRSQ SVLDELTRYN
GGLVLEALIG TCFPGWEVPA WFSHRASGSV LNPKLPPHWC DNKFTGIGLC AVIVFDGYHN
QRKRVLLKCN CEFKNEDGSS NRFCCTVGGW SEPSNTSREI VSSHVFIGFT SRLDINKISE
EDDECVCTET SVEFEVTDGM EEIRGCEVVK CGFSLVYAPE ERGNICSALK TELQ
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