ID   V4LEZ5_EUTSA            Unreviewed;       904 AA.
AC   V4LEZ5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=E3 SUMO-protein ligase SIZ1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EUTSA_v10012623mg {ECO:0000313|EMBL:ESQ42304.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ42304.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ42304.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- PATHWAY: Protein modification; protein sumoylation.
CC       {ECO:0000256|ARBA:ARBA00004718}.
CC   -!- SIMILARITY: Belongs to the PIAS family.
CC       {ECO:0000256|ARBA:ARBA00005383}.
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DR   EMBL; KI517464; ESQ42304.1; -; Genomic_DNA.
DR   RefSeq; XP_006400851.1; XM_006400788.1.
DR   AlphaFoldDB; V4LEZ5; -.
DR   STRING; 72664.V4LEZ5; -.
DR   EnsemblPlants; ESQ42304; ESQ42304; EUTSA_v10012623mg.
DR   Gramene; ESQ42304; ESQ42304; EUTSA_v10012623mg.
DR   eggNOG; KOG2169; Eukaryota.
DR   OMA; PHGSINC; -.
DR   UniPathway; UPA00886; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0019789; F:SUMO transferase activity; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016925; P:protein sumoylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd15570; PHD_Bye1p_SIZ1_like; 1.
DR   CDD; cd16792; SP-RING_Siz-like; 1.
DR   Gene3D; 1.10.720.30; SAP domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR003034; SAP_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   InterPro; IPR031141; SIZ1/2_SP-RING.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR004181; Znf_MIZ.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10782:SF4; E3 SUMO-PROTEIN LIGASE SIZ1; 1.
DR   PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02037; SAP; 1.
DR   Pfam; PF02891; zf-MIZ; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00513; SAP; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF68906; SAP domain; 1.
DR   PROSITE; PS50800; SAP; 1.
DR   PROSITE; PS51044; ZF_SP_RING; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00452}.
FT   DOMAIN          11..45
FT                   /note="SAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50800"
FT   DOMAIN          346..429
FT                   /note="SP-RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51044"
FT   REGION          84..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          800..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        806..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..854
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  100017 MW;  8EE41DF94CF80CD5 CRC64;
     MDLEASCKDK LSHFRIKELK DVLTQLGLSK QGKKQELVDR ILTLLSDERA ARLWSKKNTV
     AREEVAKLVD DTYRKMQVSG ASDLASKGQV SSDTSNLRVK GEPEDPFQPE MKVRCVCGSS
     LETDSMIQCE DPRCHVWEHV GCVIVPEKPM DGNPPLPESF YCEICRLTRA DPFWVTVAHP
     LYPLRLTATT IPTDGTNTMQ SVERTFQITR ADKELLAKQE YDVQAWCMLL NDKVLFRMQW
     PQYADLQING MPVRAINRPG SQLLGANGRD DGPIITPCIR DGINRISLSG GDNRSFCFGV
     RLVKRRTLQQ VLNLIPEETK GETFEDALAR VRRCIGGGGG DDNADSDSDI EVVADFFGVN
     LRCPMSGSRI KVAGRFLPCV HMGCFDLEVF VELNQRSRKW QCPICLKNYS VEHVIVDPYF
     NRITTKMKHC DEEVTEIEVK PDGSWRVKSK KESERRELGE LSQWHAPDGS LCPSADEIKR
     KMEMLIPVKQ EGFSDGPTPL KLGIRKNRNG LWEVSKPNTN GLSSSNRQEK VGYQDKNIIP
     MSSSATGSGR DGDDVSVNQD AIGTFDFGTN GIELDSISMN VDSGYNFPDR NQAGEDRNNE
     VIVLSDSDEE NDVVITPGPA YSGCRTDGGV NFPLNPPGII NSYNEDPNTI AGGSSRLGLF
     SDDDEFDTPL WTFPSETPEA PGFQLFASDA DVSEGLVGLH HHGSLNCGPE INGGYTMAPE
     TSMASITVVP CSDGRSESVA NDGLVDNPLA FGRDDPSLQI FLPTKPDASA QSGFKNQADM
     SNGIRSDDWI SLRLGDSACG NHGEPATANG LNSSQQMSTR EGSLDTTTET ASLLLGMNDS
     RQDKAKKQRS DNPFSFPRQK RSVRPRMFLS IDSDSETINR IIRQHTGVSK DLLYSLCRQE
     SNRY
//