ID V4LW71_EUTSA Unreviewed; 1180 AA.
AC V4LW71;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 13-SEP-2023, entry version 40.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=EUTSA_v10027624mg {ECO:0000313|EMBL:ESQ46757.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ46757.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ46757.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC ChEBI:CHEBI:456215; EC=6.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000114};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; KI517416; ESQ46757.1; -; Genomic_DNA.
DR RefSeq; XP_006405304.1; XM_006405241.1.
DR AlphaFoldDB; V4LW71; -.
DR EnsemblPlants; ESQ46757; ESQ46757; EUTSA_v10027624mg.
DR GeneID; 18022859; -.
DR Gramene; ESQ46757; ESQ46757; EUTSA_v10027624mg.
DR KEGG; eus:EUTSA_v10027624mg; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0048608; P:reproductive structure development; IEA:UniProt.
DR CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR CDD; cd00818; IleRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033709; Anticodon_Ile_ABEc.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF19302; DUF5915; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT DOMAIN 19..666
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 723..872
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 271..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 135292 MW; 198F284A50D4F796 CRC64;
MEEVCEGKEF SFPRQEENVL SFWTRIDAFK TQLKRTENLP EYIFYDGPPF ATGLPHYGHI
LAGTIKDIVT RYQTMTGHHV TRRFGWDCHG LPVENEIDRK LNIKKREQVL EMGIDKYNEE
CRSIVTRYVE EWEKVITRTG RWIDFTNDYK TMDLPFMESV WWVFAQLFDK NLVYRGFKVM
PYSTGCKTPL SNFEAGQNYK DVPDPEIMMT FPVIGDQDNA AFVAWTTTPW TLPSNLALCV
NAKFVYLKVR NKNNGKVYVV AESRLSSLPT DKPKANLANA DAKKANPKAK GGAKPESSAD
SYEVLEKFNG ASLVGKKYEP LFDYFSDFSS EAFRVVADDY VTDDSGTGIV HCAPAFGEDD
YRVCLENKII KKGENLVVAV DDDGLFTERI THFSGRYVKD ADKDIIEAVK AKGRLVKSGT
FTHSYPFCWR SDTPLIYRAV PSWFVRVEQL KEQLLENNKQ TYWVPDYVKD KRFHNWLENA
RDWAVSRSRF WGTPLPIWIS DDGEEVIVMD SVEKLEKLSG VKVFDLHRHH IDQITIPSSR
GHEFGVLRRV EDVFDCWFES GSMPYAYIHY PFENKELFEK NFPGHFVAEG LDQTRGWFYT
LMVLSTALFK KPAFRNLICN GLVLAEDGKK MSKKLRNYPP PMEVIDEYGA DAVRLYLINS
PVVRAEPLRF KKEGVLGVVK DVFLPWYNAY RFLVQNAKRL EIEGCKPFVP IDLATLQSSN
VLDQWIQSAT QSLVHFVRQE MDGYRLYTVV PYLLKFLDNL TNIYVRFNRK RLKGRTGEDD
CHTALSTLYN VLLTSCKVMT PFTPFFTETL YQNLRKACEG SEESIHYCSF PQEEGTRGER
IEQSVTRMMT IIDLARNIRE RHKLPLKTPL KEMVVVHPDA EFLNDITGKL REYVLEELNV
RSLVPCNDTL KYASLKAEPD FSVLGKRLGK SMGLVAKKVK EMPQQDILRF EEAGNVTIAE
HKLELTDIKI VRVFKRPDGL KDEEIDANGD GDVLVILDLR ADESLYEAGV AREIVNRIQK
LRKKSGLEPT DFVEVYIESL DRDESALLQV VNSQEQYIRD TIGSSLLPST MMPSHAVIIS
DESFQNVSKV SFKISLARPA LKFNEEAILA LYSGDVKYAR ELQTYLLSRD HSNLKTEFQA
GDGKITVGCI EKVPVVSVVL GEHLHLTVGD YYLLSTRSTV
//