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Database: UniProt
Entry: V4MNV2_EUTSA
LinkDB: V4MNV2_EUTSA
Original site: V4MNV2_EUTSA 
ID   V4MNV2_EUTSA            Unreviewed;       962 AA.
AC   V4MNV2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Aconitate hydratase {ECO:0000256|RuleBase:RU361275};
DE            Short=Aconitase {ECO:0000256|RuleBase:RU361275};
DE            EC=4.2.1.3 {ECO:0000256|RuleBase:RU361275};
GN   ORFNames=EUTSA_v10024325mg {ECO:0000313|EMBL:ESQ54648.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ54648.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ54648.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-
CC       aconitate. {ECO:0000256|RuleBase:RU361275}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC         ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU361275};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|ARBA:ARBA00007185, ECO:0000256|RuleBase:RU361275}.
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DR   EMBL; KI517384; ESQ54648.1; -; Genomic_DNA.
DR   RefSeq; XP_006413195.1; XM_006413132.1.
DR   AlphaFoldDB; V4MNV2; -.
DR   STRING; 72664.V4MNV2; -.
DR   EnsemblPlants; ESQ54648; ESQ54648; EUTSA_v10024325mg.
DR   Gramene; ESQ54648; ESQ54648; EUTSA_v10024325mg.
DR   KEGG; eus:EUTSA_v10024325mg; -.
DR   eggNOG; KOG0452; Eukaryota.
DR   OMA; NELPATM; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0043436; P:oxoacid metabolic process; IEA:UniProt.
DR   CDD; cd01586; AcnA_IRP; 1.
DR   CDD; cd01580; AcnA_IRP_Swivel; 1.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   InterPro; IPR044137; AcnA_IRP_Swivel.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   NCBIfam; TIGR01341; aconitase_1; 1.
DR   PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR   PANTHER; PTHR11670:SF72; ACONITATE HYDRATASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU361275};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU361275};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU361275};
KW   Lyase {ECO:0000256|RuleBase:RU361275};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT   DOMAIN          160..664
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          761..889
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
SQ   SEQUENCE   962 AA;  105185 MW;  AD3ACF7AB4BA9151 CRC64;
     MSGKMASGGA GPCIVDGFEK TDEKLCSALL NRTLDGIPTL SPDIFSVQPW SLSEEFLPTV
     ERSFLFLVKN PPENDYPLMT EQVYTWRTKQ CKREASASEH AYKDILTSLP KPGGGEYGKY
     YSLPALNDPR IDRLPYSIRI LLESAIRNCD NYQVTKDDVE KIIDWENTST KQVETAFKPA
     RVILQGVTGV PALVDLASMR DAMKNLGSDP NKINPLVPVD LVIDHSVQVD AAGTDKARLI
     IEEYEFKRNK ERFAFLKWGS SAFHNMLVVP PGSGIVHQVN LEYLGRVVFN SGGFLYPDSV
     VGTDSHTTMI DGLGVAGWGV GGIEAEAAML GQPMSMVLPG VVGFKLDGKL REGVTTTDLV
     LTVTQILRKH GVVSKFVEFY GEGMSKLSLA DRATIANMSP EYGATMGFFP VDHVTLEYLK
     LTGRSDETVA MIESYLRANN MFVDYSEPQQ ERAYTSYLQL DLGHVEPCIS GPKRPHDRVL
     LKDMKADWHA CLDNPVGFKG FAIPKEKQED TVKFLFEEKL PAELKHGSVV IAAITSCTNT
     SNPSVMLGAA LVAKKAYDLG LMVKPWVKTS LAPGSGVVTK YLDQSGLQEY LDKQGFQIFG
     YGCTTFIGNS GNLKKSVESA IKNNDVVVAS VLSGNQNFEG RVHPLTRANY LASPPLVVAY
     ALAGTVDIDF EKEPIGTGRD DKSVYLRDIW PTNEEIAQVV QSNVLSDMFK STYKTITEGN
     PLWNELPATM KDAYCLLNFG DSITTDHISP AGDIQKDSPA AKFLIDNGVS QEDFNSYGSR
     RGNDEVMARG TFASIRIVNK LADGEVGPKT VHIPTGEKLT VFDAASRYKT AGQDTVILAG
     AEYGSGSSRD WAAKGPLLLG VKAVTAKSFE RIHRSNLAGM GIIPLCFKAG EDADTLGLTG
     HERYTVHLPT KVSDIRPGQD VTVTTDTGKS FVCTLRFDTE VELAYYDHGG ILPYVIRSLS
     TK
//
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