ID   V4NGQ8_EUTSA            Unreviewed;      1216 AA.
AC   V4NGQ8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=EUTSA_v10010076mg {ECO:0000313|EMBL:ESQ45356.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ45356.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ45356.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR   EMBL; KI517435; ESQ45356.1; -; Genomic_DNA.
DR   RefSeq; XP_006403903.1; XM_006403840.1.
DR   AlphaFoldDB; V4NGQ8; -.
DR   EnsemblPlants; ESQ45356; ESQ45356; EUTSA_v10010076mg.
DR   Gramene; ESQ45356; ESQ45356; EUTSA_v10010076mg.
DR   KEGG; eus:EUTSA_v10010076mg; -.
DR   eggNOG; ENOG502SI7S; Eukaryota.
DR   OMA; PEHIFIG; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR045344; C-JID.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR011713; Leu-rich_rpt_3.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF565; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF20160; C-JID; 1.
DR   Pfam; PF07725; LRR_3; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT   DOMAIN          17..179
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1216 AA;  138597 MW;  BD9216C0AE9C5C80 CRC64;
     MEEVSSSSKS KPFHLPPQHL VFVNFRGKEL RNNFVSHLRN ALQRHGVNIF IDTNEQKGKP
     LNVLFQRIEE SRIALAIFSV KYTESKWCLN ELVKMKECMD KGKLLIIPIF YKVKAYHVRF
     QRGRFGYVFK NLRNVDDDKK NQWSEALSSV ADRIGFCFEG MSDENDFINC IVEEVKQALS
     KIPLDGTNEN FVHLSKNTSM RLGKDNHEIY GLRQRLEELE EKLDLGCQET RILGVVGMPG
     IGKTTLAREL YETWQCKFVS HGLIQDIRRT SKELGLDCLP ALLLEELLGV KIPDIESTQR
     VYESYRSKLL RHKVLVVLDD VSDKKQIEVL LGRCDWIRQG SRIVIATNDK SLIQDVVDYT
     YVVPQLNHRD GLGHFGRYAF DHHSNKLNKK VIMKLSKEFV HYVRGHPLAL KLLGEDLNGK
     DEDHWRTKLA ALEQNCWQCM RDVLDVSYDE LSQVHKDIFL DMACFRMEDE SYVASLLDTS
     EAASEIKTLM NKFMIDVSDG RVEMHDLLYT FAKELCRRGY AQDGTEGHRL WHHQDITDVL
     KNIEEGAEVR GIFLNMNEMK REMSLDSRTF EPMRNLRYLK IYSSHCPQQC KPNNKINLPD
     GLNFPLKEIR YLHWVEFPLK EIPPDFNPHN LVDLKLPYSK IERIWSGDKD TSKLKWVNLN
     YSSNLRVLSG LSKAQNLQRL NLEGCIAMET LPHDMEYMRS LLFLNLKGCI SLNCLPEINL
     VSLETLILSN CSGLKEFRVI SKNLEALYLD GTSIKELPLN INILQRLALL NMKGCTKLKE
     FPDCLDDLKA LKELILSDCS KFQSISATGE GIKVLEILRL DATAITEIPK ISSLQCLCLN
     KNDQISSLPE NISQFSQLKW LDLKYCKSLS SIPKLPPNLQ HLDAHGCCSL KTVSNPLACL
     MTTQQIYSTF NFTNCNKLER SAKKDISSFA QRKCQLLSDA HNCCDVGSDL EALFSTCFPG
     SELPTWFCHK AIGSVLELRM PPQWHENRLA GLALCAVVSF PDSQEQIRCF SVKCTLKLKV
     KEGSWIEFVF PVGSWGNQGN IVENIASEHV FIAYNSCSKI FKRLENQDLG CSIPTKSTQP
     NICSPTMASL NFTIVDDTCE IPRLEVLKCG LSFFIDGERS GNYIKKLEVA EAEQIRSAEK
     VSENCTSGSG SRCTDVVKRR PIQSLEPVTT DVVASPEPAN NVDFQTKIVP REAQLHTCSK
     PSKWACFPCC NSAKHL
//