ID V4P566_9CAUL Unreviewed; 869 AA.
AC V4P566;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AEAC466_18225 {ECO:0000313|EMBL:ESQ82284.1};
OS Asticcacaulis sp. AC466.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Asticcacaulis.
OX NCBI_TaxID=1282362 {ECO:0000313|EMBL:ESQ82284.1, ECO:0000313|Proteomes:UP000017826};
RN [1] {ECO:0000313|EMBL:ESQ82284.1, ECO:0000313|Proteomes:UP000017826}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AC466 {ECO:0000313|EMBL:ESQ82284.1,
RC ECO:0000313|Proteomes:UP000017826};
RX PubMed=24463524; DOI=10.1038/nature12900;
RA Jiang C., Brown P.J., Ducret A., Brun Y.V.;
RT "Sequential evolution of bacterial morphology by co-option of a
RT developmental regulator.";
RL Nature 506:489-493(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00244}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESQ82284.1}.
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DR EMBL; AWGE01000020; ESQ82284.1; -; Genomic_DNA.
DR AlphaFoldDB; V4P566; -.
DR STRING; 1282362.AEAC466_18225; -.
DR PATRIC; fig|1282362.3.peg.3609; -.
DR eggNOG; COG5001; Bacteria.
DR Proteomes; UP000017826; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR005330; MHYT_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF03707; MHYT; 2.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF12860; PAS_7; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50924; MHYT; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00244};
KW Reference proteome {ECO:0000313|Proteomes:UP000017826};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00244};
KW Transmembrane helix {ECO:0000256|PROSITE-ProRule:PRU00244}.
FT TRANSMEM 28..50
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00244"
FT TRANSMEM 59..80
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00244"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00244"
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00244"
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00244"
FT DOMAIN 1..145
FT /note="MHYT"
FT /evidence="ECO:0000259|PROSITE:PS50924"
FT DOMAIN 194..240
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 269..321
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 483..615
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 624..869
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 869 AA; 94425 MW; 5AAF6A31DB5DFAA2 CRC64;
MACGFGIWAT HFVAMQAFNP KMGLAYDLTL TLVSLVCAMA ITTGGIEIAV SRAFPHARLV
GGSVLGSGIA TMHYLGMMAL DVPGYVEWAP DLVIASILIS LLLGALALWT ITLPARSPLR
RLGGLILLLT IVGHHFTAMG AVTIRLDAAR KISGLVLSPQ AMSLAITVTA IAVLSLCVFA
VVSARRLDSL RADTDRRFRV LLEGMEDYAI FMLDTRGNVV DWKAGGDRIN GYLASDIVGR
CYADVCAADA AFPDDYRAAL IKAAKEDRAE IEGPARRANG KIFWSHTLLR ALRDDDGKLL
GFANITQDIT ERKTTQDRVI ASARNLDAAL SNMPLGLLLF DRNEHLILAN SRFSELYGLD
PAFMAPGLTF RALSDHIVSI CLGRSVDPET LAMHHARHME LITKPGGGTM VSDLFQARSM
SISHRPTSDG GWVSTFEDVT ERRLSEQRIA HISRHDGLTA LPNRLHFNEY LDQELTAAAR
NGEQVAVIIA NLDRFKDIND QRGHSAGDTV LKAVARRLSD AANSCGLIAR FGGDEFAIVK
RFDRRETVEA RIAALNDAVS VPISLDGGPI AIQASFGVAL YPGDGSSRET LLNNADLALN
RAKNNAAQKV CFYDSGMDEA ERHRRALAAD LDIALANEEF RLFYQVQHSV RTGEITGYEA
LIRWKHPERG FISPAEFIPI AEESGAIVAI GAWVLRAACL EALSWPNTAK IAVNLSPVQL
NDITLIETVK SVLIETGLSP SRLELEITET TIIGDKVRAL HLLRQIKALG VTIAIDDFGT
GYSSLDTLNS FPFDKIKIDR SFLMEADKSP QARAIVRAIL ALGKSLGIPV LAEGVETESQ
LGLLREEGCD EAQGYLLGRP VEFIDRKAA
//
