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Database: UniProt
Entry: V4P5Z1_9CAUL
LinkDB: V4P5Z1_9CAUL
Original site: V4P5Z1_9CAUL 
ID   V4P5Z1_9CAUL            Unreviewed;       739 AA.
AC   V4P5Z1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   08-MAY-2019, entry version 33.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ESQ80670.1};
GN   ORFNames=AEYBE204_05205 {ECO:0000313|EMBL:ESQ80670.1};
OS   Asticcacaulis sp. YBE204.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Asticcacaulis.
OX   NCBI_TaxID=1282363 {ECO:0000313|EMBL:ESQ80670.1, ECO:0000313|Proteomes:UP000017808};
RN   [1] {ECO:0000313|EMBL:ESQ80670.1, ECO:0000313|Proteomes:UP000017808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YBE204 {ECO:0000313|EMBL:ESQ80670.1,
RC   ECO:0000313|Proteomes:UP000017808};
RX   PubMed=24463524; DOI=10.1038/nature12900;
RA   Jiang C., Brown P.J., Ducret A., Brun Y.V.;
RT   "Sequential evolution of bacterial morphology by co-option of a
RT   developmental regulator.";
RL   Nature 506:489-493(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESQ80670.1}.
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DR   EMBL; AWGF01000002; ESQ80670.1; -; Genomic_DNA.
DR   RefSeq; WP_023461341.1; NZ_AWGF01000002.1.
DR   EnsemblBacteria; ESQ80670; ESQ80670; AEYBE204_05205.
DR   PATRIC; fig|1282363.3.peg.1033; -.
DR   OrthoDB; 977512at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000017808; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017808};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017808}.
FT   DOMAIN      326    509       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      513    608       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   739 AA;  78855 MW;  29011A0A100E8436 CRC64;
     MENFKTELDA DGILLATFDV PGKSMNTFTK SALADLSAIA ERAKTDAEVK GVVITSGKTT
     GFCAGADLEE MLGGAWEAKS DPNDPEGALK AGFTAAFEMN RVYRQLETCG KPVAVAINGL
     ALGGGLELSL ACHYRVLNDG PKTQVGLPEI KIGLFPGGGG SQRLPRLIGA QAALMAMSEG
     KSFKPKEALQ AGIVHEVVPV GQEVEAAKNW IKTKGDAVAL WDKKDYKIPG GGPYHPAGAQ
     VFIMGNALLR KQSYGNYPAV VNLMRAVYEG LQLPFDTAIR VESRYFVNTL QTPQAKAMIR
     TFFFNMQALG KGGGRPAGQP KTDPQQVAVL GAGMMGAGIA YVSALAGIKV ILIDRDDAAA
     SKGKSHCESL LKKAVSRGKM TQEKAQSVLD LIVPTPDYGQ ITGSDLIIEA VFENAELKAT
     VTKDAEAKLY AGDKADTAIF GSNTSTIPIS QLAKASGKPE NFIGIHFFSP VDKMLLVEII
     TTDTTSDATL AKAMDYVLKI KKTPIVVNDS RFFFANRCFI PFTAEGMTMW SEGIAPSIID
     NVGRMTGMPR GPLEMMDDVA LDLLVKITSE TAKAMGDAYV PIPGEKEVAA MVADGRLGRK
     NGKGFYDYPE AGGNKSLWSG LSDKFVVTTD EAEPELVEEI KKRLLYIQAV TAARCFEEGV
     ITDPREADVG SILGWGFAPW SGGIVSLIDS IGAAKFVEEL DALAAKHGDR FAPPQLLRDM
     AAKGETFYGR FGKKEAKAA
//
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