ID V4XFC3_9ARCH Unreviewed; 520 AA.
AC V4XFC3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Xanthine/uracil permease {ECO:0000313|EMBL:ESS06769.1};
GN ORFNames=A07HB70_01040 {ECO:0000313|EMBL:ESS06769.1};
OS uncultured archaeon A07HB70.
OC Archaea; environmental samples.
OX NCBI_TaxID=1412872 {ECO:0000313|EMBL:ESS06769.1, ECO:0000313|Proteomes:UP000030648};
RN [1] {ECO:0000313|Proteomes:UP000030648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24335829;
RA Podell S., Emerson J.B., Jones C.M., Ugalde J.A., Welch S.,
RA Heidelberg K.B., Banfield J.F., Allen E.E.;
RT "Seasonal fluctuations in ionic concentrations drive microbial succession
RT in a hypersaline lake community.";
RL ISME J. 0:0-0(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; KI543179; ESS06769.1; -; Genomic_DNA.
DR AlphaFoldDB; V4XFC3; -.
DR STRING; 1412872.A07HB70_01040; -.
DR PATRIC; fig|1412872.3.peg.1085; -.
DR Proteomes; UP000030648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; NF037981; NCS2_1; 1.
DR PANTHER; PTHR11119:SF3; LD30822P; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 520 AA; 52971 MW; EFBA49BB846631B9 CRC64;
MSDGGDGRGG SLVEYGIEDR PPLLRSLGLG VQHYLTMVGA NIAVPLILAG AMGMPEQFVP
RFVGTFFVVS GVATLAQTTF GNRYPIVQGA PFSMLAPALA IVGVVAANPP GGGVAAWRAA
LLQLQGAIVV AALFEVAVGY LGLVGRLRRY FSPVVIAPVI VLIGLTLFTA PQVASATQNW
PLLLFTFGLI AVFSQLLGDR SRAFQLFPVL LGIVVAYLVA LGLSAAGVYA PGTPGYVDLT
PVVDAPLAVA IYPLQWGVPQ VTTSFVVGML AGVIASVVES LGDYHAVARL SGTGAPSGKR
ITHGIGMEGI ANVFAGLMGA GGSTSYSENI GAIGLTGVAS RYVVQVGAAT MLVVGFFGPF
GALVASIPAP VVGGLYVAMF GQIVGVGLSN LEYVDLDSQR NLFVLGVSLF AGLAVPEYFS
NVAAAAPDGV GGAAFFAQSM AAVPALGPVL GAEVVANTVF VVGSTGISVG GIVAFALDNA
IPGTDEERGL SGWARTAEAD EDFLSAYDRF VRGGDETRAD
//
