ID V4YB10_9ARCH Unreviewed; 368 AA.
AC V4YB10;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Pyruvate dehydrogenase E1 component, alpha subunit {ECO:0000313|EMBL:ESS12168.1};
GN ORFNames=A07HR60_01108 {ECO:0000313|EMBL:ESS12168.1};
OS uncultured archaeon A07HR60.
OC Archaea; environmental samples.
OX NCBI_TaxID=1412874 {ECO:0000313|EMBL:ESS12168.1, ECO:0000313|Proteomes:UP000030679};
RN [1] {ECO:0000313|Proteomes:UP000030679}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24335829;
RA Podell S., Emerson J.B., Jones C.M., Ugalde J.A., Welch S.,
RA Heidelberg K.B., Banfield J.F., Allen E.E.;
RT "Seasonal fluctuations in ionic concentrations drive microbial succession
RT in a hypersaline lake community.";
RL ISME J. 0:0-0(2013).
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DR EMBL; KI543229; ESS12168.1; -; Genomic_DNA.
DR AlphaFoldDB; V4YB10; -.
DR STRING; 1412874.A07HR60_01108; -.
DR PATRIC; fig|1412874.3.peg.1268; -.
DR Proteomes; UP000030679; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:ESS12168.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030679}.
FT DOMAIN 37..332
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 368 AA; 40479 MW; 129E105390EFA5FA CRC64;
MSILDRAPGD TVRVLDDDGK IVGEPPALTA AELVEMYRFM KLGRHFDTRA VRLQHQGRMG
TYASMSGQEG AQVGSCFALG DSDYIVPTYR EHIAAAVQGH PLEQTLRYWM GSEQGSVSPT
DVNVFPVAIP IASQIPHATG AAWAGKMRAD GEPPVFLCYF GDGATSEGDF HEGLNFAGVF
DTPSVFFCSN NQWAISTPRD RQTASETLAQ KAIAYGFSGV QVDGMDPLAV YKTTQAAVDR
ARDPPDGELR PTMIEAVMYR FGAHTAADDQ TVYREQEEVD SWKQKDPIPR LETYLRDKAI
LDDDTVATIE DGVEKQVAEA IDAAEAAPQP HPDEMFDNVY QEPTPELESQ REILAQLRET
HGDEAFLE
//
