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Database: UniProt
Entry: V4YB30_9ARCH
LinkDB: V4YB30_9ARCH
Original site: V4YB30_9ARCH 
ID   V4YB30_9ARCH            Unreviewed;       379 AA.
AC   V4YB30;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   08-MAY-2019, entry version 29.
DE   SubName: Full=Urea amidohydrolase (Urease) alpha subunit {ECO:0000313|EMBL:ESS08302.1};
DE   Flags: Fragment;
GN   ORFNames=A07HN63_02324 {ECO:0000313|EMBL:ESS08302.1};
OS   uncultured archaeon A07HN63.
OC   Archaea; environmental samples.
OX   NCBI_TaxID=1412873 {ECO:0000313|EMBL:ESS08302.1, ECO:0000313|Proteomes:UP000030667};
RN   [1] {ECO:0000313|Proteomes:UP000030667}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24335829;
RA   Podell S., Emerson J.B., Jones C.M., Ugalde J.A., Welch S.,
RA   Heidelberg K.B., Banfield J.F., Allen E.E.;
RT   "Seasonal fluctuations in ionic concentrations drive microbial
RT   succession in a hypersaline lake community.";
RL   ISME J. 0:0-0(2013).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR611612-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR611612-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR611612-50}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases
CC       superfamily. Urease alpha subunit family.
CC       {ECO:0000256|RuleBase:RU004158}.
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DR   EMBL; KI543219; ESS08302.1; -; Genomic_DNA.
DR   Proteomes; UP000030667; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030667};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700,
KW   ECO:0000313|EMBL:ESS08302.1};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR611612-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030667}.
FT   DOMAIN      135    379       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    322    322       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       140    140       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       142    142       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       219    219       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       219    219       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       248    248       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       274    274       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR611612-51}.
FT   METAL       362    362       Nickel 1. {ECO:0000256|PIRSR:PIRSR611612-
FT                                51}.
FT   BINDING     221    221       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     219    219       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR611612-50}.
FT   NON_TER     379    379       {ECO:0000313|EMBL:ESS08302.1}.
SQ   SEQUENCE   379 AA;  40282 MW;  CE4170176D5FFC74 CRC64;
     MSRELSREAY TDLFGATEGD RLRLGDTNLL AEIDEDHGTY GDEAVFGGGK TMRDGMGMQS
     GTTQAEGALD WVFSNAVIID PVMGVQKGDI GVRDGKIAGV GKAGNPDTMD GVDDDLVIGA
     STDTAPADGL IATPGALDIH IHFNSKELFE HALASGVTTM FGGGYGGGAT TCTTGPENIK
     RFLQAAEEYP VNAGFYAKGN NSSPEPIMEQ IEAGACGLKL HEDWGSTPDA VDTALTVADE
     EDVQVCIHTD TLNESGFLED TYEAIDGRTI HTFHIEGAGG GHAPDVLELI GHDHMLPSST
     NPSMPYTVNT FDEHLDMVMV CHHLNPDVPE DVAFAESRIR SETIAAEDVL HDMGAISMMT
     SDSQAMGRMA EVIARTWQT
//
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