ID V4Z547_TOXGV Unreviewed; 605 AA.
AC V4Z547;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
DE Flags: Fragment;
GN ORFNames=TGVEG_283900B {ECO:0000313|EMBL:ESS30528.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS30528.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS30528.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAYL02000243; ESS30528.1; -; Genomic_DNA.
DR AlphaFoldDB; V4Z547; -.
DR STRING; 432359.V4Z547; -.
DR PaxDb; 5811-TGME49_083900; -.
DR EnsemblProtists; ESS30528; ESS30528; TGVEG_283900B.
DR VEuPathDB; ToxoDB:TGVEG_283900B; -.
DR eggNOG; KOG1514; Eukaryota.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 114..322
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 42..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 605
FT /evidence="ECO:0000313|EMBL:ESS30528.1"
SQ SEQUENCE 605 AA; 67065 MW; E3D4F4D8539A808B CRC64;
ARRAGRERRR HPSKRVFVSE CSLLQKLLRC SCFYLRFYDA SHQGGSRSEA PRASLTSAGE
QEQSGKEDTP HHQLVQRAVR RLQLDNIPDT LPCRTKECLQ VRQFIRSSVL QSGNGEVLYV
SGLPGTGKTA TVQTVVRGLQ DEVEQGILPP FDVVDVNAMR LPHPDFLFSV LHRRFFGTKA
KSTQQAFAAL DRYFTSSRVR GEKARGRGRD GEASSGEDRE DGEEENYFTY CDSKGRRRGA
SSQGDWANRI VRRGRDRRPC LLIVDEVDCL LTQKQRVLYT LFDWPTQRTA RLIVVGIANT
IDLPDRFLSS RCASRVGFGR LTFNPYTREQ IEEILLARLQ ECKYLFNEAA IKVCARKVAN
FFGDLRRALQ VLRRALEMRQ AEGVICPADI AKAANDLFDS PIKDAITALP WGLKLLLFSL
LQAQRVDGGG VSLLQLRDRF QGILMSWQSG ACKTDAEGKG AGEEAEGDGP LRASLASTQS
VTYDELKTMV DVLVQLNVVR LGFYLPRVEA PSGSAADCLP EETALPSLQR SSRPGEGGRS
QTTSPQKRRN ASAAYASLGL SQGFGPLRVD PVVDELGGDM QVAIAVPLED VSSAFMADPD
FRSLL
//
