ID V4ZCB0_TOXGV Unreviewed; 3802 AA.
AC V4ZCB0; A0A0F7USR6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Amine oxidase, flavin-containing domain-containing protein {ECO:0000313|EMBL:CEL73074.1};
DE SubName: Full=Histone lysine-specific demethylase {ECO:0000313|EMBL:ESS31541.1};
DE EC=1.4.3.4 {ECO:0000313|EMBL:ESS31541.1};
DE EC=1.5.3.13 {ECO:0000313|EMBL:ESS31541.1};
GN ORFNames=BN1205_102510 {ECO:0000313|EMBL:CEL73074.1}, TGVEG_242415
GN {ECO:0000313|EMBL:ESS31541.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS31541.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS31541.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS31541.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS31541.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS31541.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL73074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL73074.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714495; CEL73074.1; -; Genomic_DNA.
DR EMBL; AAYL02000173; ESS31541.1; -; Genomic_DNA.
DR STRING; 432359.V4ZCB0; -.
DR PaxDb; 5811-TGME49_042420; -.
DR EnsemblProtists; ESS31541; ESS31541; TGVEG_242415.
DR VEuPathDB; ToxoDB:TGVEG_242415; -.
DR eggNOG; KOG0029; Eukaryota.
DR OMA; ADIFWER; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0052899; F:N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0052904; F:N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0052903; F:N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0052902; F:spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; IEA:UniProtKB-EC.
DR GO; GO:0052901; F:spermine:oxygen oxidoreductase (spermidine-forming) activity; IEA:UniProtKB-EC.
DR CDD; cd15489; PHD_SF; 1.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10742:SF342; AMINO_OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ESS31541.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 1888..2069
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
FT REGION 1..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1524..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2112..2148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2404..2451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2463..2502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2547..2621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2736..2825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2903..2932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2995..3020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3050..3075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3130..3319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3377..3430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3497..3518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3749..3802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..804
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1700..1716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1717..1745
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2404..2447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2559..2602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2750..2775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2802..2825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2911..2929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3130..3154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3162..3215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3247..3281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3389..3403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3497..3516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3802 AA; 413649 MW; 39711855843F353F CRC64;
MEENPEDAAK RIRLLPDIPK GLLPPLLSPV PRSASSPQLS SSASSPVITN ANSDTVGRPP
ERKTGSENAS AETGRNGRRK VKVLTDLEAC SAETTNKSED RGTETNGTTH GEDGEAWESC
RAGDKPTPLR HLSRNSTPDC SASSHLPSSP TSGRPQRHVM RSKYTDMLKG KWTPPASRCL
EEMKEKRSRK RRKTDSDRGR GAPQLSNCPA LQLKKQRRVF SEEVCGERRV PGSRECQPVG
LGASVSAYSF VNSPFFLENQ SFALPSHSPT PSSLRTPKIT GLFGHLDLLS PPSSVASPSA
PEGKTGVPSP RNFSSGSAAP ADRASSSSLF QQSQSPLGSS AFKTLAGGLS VPWKSELVAA
SPVPSSPQRG SEKISWNGAR DGTSAGSSGQ KEVLLQRHEK VTETKDSIPL CRRAICGAVP
PVDLLGFGLP ARELATVLLR KRREAQNLPR RLSQGETDHR EAAKKPNQTG VFVPSERHMS
TAGHQTGNLH PGRDPRLQTF SLSSSASSVQ MPPSPSLAPS SLPLSPKACF PSPSSSLFPF
RLGLSAAQEA KVPRVQKFAL KCDCVVVGAG VSGLAAAAYL RRCGAKVLLL EARSRVGGRT
FTTRLPAREL PGGRTVKDIQ VDLGANYMHC VTRFRRRQKR AAPPGRLGAR KGQGASFSAA
TKATFSGADA SEATKKNLPE ARPLRDCRWR REPSRSVSGI AAILRPLVAD VCGKQNWEST
FFCNWYDDGT GTRISPASVV RVSHVLELIR QRAAAKLAHF PAPSASSEPA KERETTQEQF
GRHSKETKAM DRNPERREQE AKAVDKSSGQ ASSPSQSSEA PETGNVVACK VYPELSAAAS
SMLRVSPSSA SAPLASESPV ASLVPGCVVF PTSEVAEVVP GPTAFPLSCS HAAADCFAVP
LRAHLKKRLK SETTDSPPQS TLSGERFNAN AASSATRGEE AGTQEEDREG TIGGEGGGEK
ADNSRGLGLW PDAHTSSSGG VTAGSELCPC VCGASEEEAS SLNGRRVPVL KAGTVETVSL
EPDDGRTREK KRRNRIPLIA SSAFPAYYPL GEALLRSSPG LEGDDAACDP APERPSPRVS
LGVSKSPPAS RQGGRFASAC CTVCCTGQCR KRRVRRQPQD RGEEEFERTY HAESGTLEGV
QREKRSGRRK AHASSLWRDR EENNGSETGE KSDAGGGKRD ARGPCSPGQM SIDQQDREHG
FSSPSDTRDA LSNADGSHVQ SLFTGDGRRN LSGDTSASKG GHENFSSPSS LPSSSSLPSS
SVPSLRLHEH SVVRPVFPVA VCTDSGCRRS AWDVLEECVR EVLEEECLPV SPFPQPGEEG
ERPPSGVLSP GSACKPLGSE KRSRKGSPSG GWEATRRVPQ THCGPRRQSP TREEDAAGRS
KFTLTEGELS AAVSASTEKG RRAPSCRSSN ACALSEQEMR MLFVQLQSRL GYVGDLREQS
VSALRNFPFE VAVLNSHGQA RLQATPREAQ TPGHGQPALL SPSPLSLETP TSAPLSPPSS
RGLLAASAVP SSLSVQSSAY ADAEPESFSQ LPTLPLWPPR SGKERKPSEP LQRDPEKCIS
APGASVALRE EVQQKASKGR QTLEGELTVE QREAAGRRQA LEGRMALQGR QASEPLSLIR
AFPMHQANGF LRSQQQQLIY TLQREQQQPG PRVNPFNAWT ASGADKIVVE GWNFLPAFLA
LQVHPFVLTG AVADSVEVRQ PPDELDKASQ PDEETDKGQE EKDEEDKDTE EKSDKEEEEE
DREEERDKEK EGGEEEDLSL WPVRVRVRAP LETEKFKQSE GVHFRRKQGA PEGEEDLRQE
ASGEKKRIFE ADAEENSDAI VFDVYAKFAI VAAPVSQLGE SFPGAGSTDR VTAFRTRKKA
LKTFPDDKKV DGETQEDLLP ALPRSSGLLQ FDPPLSLEKQ QALTRIAMGV HNKVILRWHP
ADIFWERTQL QLNCLDQKFQ FLNLHAYGKE GCLLAHSFPP FSNGYGGLQS DDAVVAEVLA
VLQRMFGLPD KKFPPPVDFI VTRWQDDPFA RGSYSFPAVN AFDDDTEILR TPHPAENPRV
LFAGEYVSKA YFQCVDGAFD TGLRAAECVA HEGLHLPLPP REDRTPLALD VFTGCLSSRQ
ADACSEFALA SPAKKREANQ EKREGNRAKR EGKRRKRQKR RENELSLSTH MLTPCPFTGF
PVPSVPTALR GYYITDMSDA GLTDGEGSGP ELSFSLSAEG RRCSAGKRAE LELCEERFLR
RCLEFLEAGG EEEKGKGAKE DSGLLGGFFS FPSQRFFYDA FFGHPTLCGS EENRVPCSGE
SGRRSSFADP TVLCAVLTSA LAFTREEIEE ALATHARQGR SSIRGSFFSD ADASAAVEGK
VEREGVELRR SALRLDEQAV EPVSEEFQEL RDFLAFLGTR DPFARRRLLL PLWVAAQSAR
ERRGQVKGLE EVDEERRGAS NEDEPQETEA SLARETVETE RGKADDEGVA SCAASSPLIE
RRFGAEGREQ VNRRARRTAT TVAEDRLSHA ESELDSEGEG AERKERQRVR WVYLRAAEVL
TRHARAAAFL PSLSPVGLAS FLVDSLPRLP PKKRTGASAK SGRTADRETL RTLREKKSRN
SDLAAHATRA HTHEDAENTP DLVERSRSFP PSLSREVSPE CGNETRMALI VSRSQAEREN
IRGDCGGVKG GCSEEKTEKN SRSLGVTRKV LKGARRRLPT ASEFKRELEN RLLHHLARSA
FPSDIEATAL RELLRAAQDE RDIISCCHRR QAEAGKGVAK EDLEVQGDSS CLSPAFTESI
ERQTTQRSAE SEGGETASRY QGLRSGLRGQ TEEGNEVEVT GANAGDEREF PHAGPKSGES
EHFDYGSEDD FELREGGLLS DSEGEKGSYH ERLCWMCGVG GDLLLCDGEG DPDMRRERTA
SREEKGSSTF VTLSRELTAN EERKALPSFE IPRTSASQHH LSPRSQRPRI LSPSPRRCRR
VFHLACIFPP PTDEELQQDA VWRCPVCRFR SEERQRASGF GDGLVPSSLA LHEETASARE
HIQESTPEPG EKSRGRDESQ RRSVQSFSFF SSSSASSCSS LASSSSYPSS FPPAVSGSVA
KGQGGTSGAQ TAVHTPRELR RFGTLSSLAL HRVSLKKLFV EEVKCLLSTT RRVRRRFDFL
ARQRERREAV QQRKAQRRRC AEQKREEQRR RKLGKAAKSA PRGAEADGER VGERNGDRED
VGKEQHAREC SEEEREQHQQ HTKERSEEKR EGRDGCLCQP AVSSEANGAE EQTEGKVKRR
KRGRVVLAKN REGERQGDGE KQETLEEKLT VSEEPKRTIR TRSSVAVRPA TNEESDGEKS
EDENGDEDLF TEDGRPVDPF LTASKDSRFA FALQVLNEFR EANAVSPCHL PLARLAWHIQ
AGCRCCTYSA AEPGDEKADA EKEDASRGGD SSLLSSVRSS GESNRGLGGK GESRGGWKAP
HCARGDSKNA GDSWCCCGCG REESEGDPEK KGRNCRCDLA NLEAAAEAVA TLACDAAPGA
FEERARRDEE LRMRCEIDGE EKRKTGMEKP RKRTSDLPQR FSAACSLESE KSSFLTPSAE
ARERHERFWR PDVSSRFQSR ASNSLKFLSR FATSPFVPRC FSQPTTSVRS HGLLSTARQP
VKAGQFNSFP SRSFTSRSPT SNIVTSNIAT SNIATSNGVT SNSFISSSPT SNNLTSTTLS
SRDFVVASGL PGVPESVSLS PAGSRALAAN CSVSVAPRDK EHPGSLSTAC VSGENGGRLS
PAPPVNVPCF SRGPMKAAAK ARPFLRGGQS RVMPANKSGA VRLPARMPDH PEGRPPENDS
MQSPAPGEAL QSVPDGNAAR PM
//
