ID V5A2Q8_TRYCR Unreviewed; 526 AA.
AC V5A2Q8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS55055.1};
GN ORFNames=TCDM_13496 {ECO:0000313|EMBL:ESS55055.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS55055.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS55055.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS55055.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS55055.1}.
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DR EMBL; AYLP01001061; ESS55055.1; -; Genomic_DNA.
DR AlphaFoldDB; V5A2Q8; -.
DR EnsemblProtists; ESS55055; ESS55055; TCDM_13496.
DR VEuPathDB; TriTrypDB:TCDM_13496; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..195
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
SQ SEQUENCE 526 AA; 55726 MW; D7132464A83ABCEE CRC64;
MRLMGSGGSG VGTEGNSLVF PVEGTKNGED GKKKTVSLII YSSDTVSWTL SKGMSADGCS
VPSVVEWKGK LMMMTACDDG RRRVYEINGR GDSWTEALGT LSRVWVNPTE NGKGFRSGFT
TATIRNGDDE KNVMLATVPV YANEKGNGKG MLHLWLTDNT HIVDIGSVSG DDDVAASSLF
YKNGNNNEEL IALYEKKGGG QPSPGVASVL LTAQLRRVKE VLATWKKVDK RVSKLCPSPG
TAKGTSTGNA CSTVRITDGL VGFLSGNFSG NTWRDEYLGV NATVTKGVSS GPVDGVTFGG
VGAGAQWPVG KPGQNQLYHF ANYNFTLVAR VSIHEAPESG SVPLLGARMN DDKSTVLLGL
SYNNEKKWEL LSSGGTNKEH NSKWEPEKTY QVAIVLRNGK QGSAYIDGQR VGDAQFELKN
TGSKGISHFY IGGDGGNTGS AASQEVSVTV MNVMLYNRPL SAAEISVLNA NKPTIPKILH
SKTVAAGATG EDAARKRRAH GNGCTVCGFG LLPLLLLLGL WGFAAL
//
