ID   V5A585_TRYCR            Unreviewed;       432 AA.
AC   V5A585;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS55930.1};
GN   ORFNames=TCDM_12571 {ECO:0000313|EMBL:ESS55930.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS55930.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS55930.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS55930.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS55930.1}.
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DR   EMBL; AYLP01000618; ESS55930.1; -; Genomic_DNA.
DR   AlphaFoldDB; V5A585; -.
DR   EnsemblProtists; ESS55930; ESS55930; TCDM_12571.
DR   VEuPathDB; TriTrypDB:TCDM_12571; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          92..432
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  46759 MW;  C8BB8B2FB011FBE5 CRC64;
     MLSRVAAVKA PRTHNRRRVT GSSGRRREGG ESEWQRPNMS RRVFTSAVLL LLVVMIFCGT
     GAALAEVKLS SETKFQWKGI SEGDVTVESL GAPSLLKVGS DVFAVAEAQC KKGGDNVFTG
     IASQLLTMDK GKEPKEVLKE NKDKIQVLEE LTSSEAKKVH VSRPTTVVTA DNNYMLVGKY
     SRTPATGGAD DWGLLLVKGT VSDKEESNKQ IDWKDTNALP KTPLGEQLSS LKRLIGGGGS
     GVKMKDGTLV FPVEGTKKKD GTEDDGKTVS LLLYSSDAEN CTLSKGMSDD GCSDPSVVEW
     EKDKLMMMTA CDDGRRRVYE IGDKGNTWTE ALGTLSRVWS NNQKEGEAKA VGSGFITATF
     GDEQKNVMLV TLPVYAKENE KGKLHLWLTD NTHIVVIGPV SEKDDDVAAS ALLYKSAGSG
     TDEEKKEELI AL
//