ID   V5ANA1_TRYCR            Unreviewed;       846 AA.
AC   V5ANA1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS62195.1};
GN   ORFNames=TCDM_10166 {ECO:0000313|EMBL:ESS62195.1};
OS   Trypanosoma cruzi Dm28c.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS62195.1, ECO:0000313|Proteomes:UP000017861};
RN   [1] {ECO:0000313|EMBL:ESS62195.1, ECO:0000313|Proteomes:UP000017861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dm28c {ECO:0000313|EMBL:ESS62195.1,
RC   ECO:0000313|Proteomes:UP000017861};
RX   PubMed=24482508;
RA   Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA   Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT   "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL   Genome Announc. 2:e01114-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESS62195.1}.
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DR   EMBL; AYLP01000203; ESS62195.1; -; Genomic_DNA.
DR   EnsemblProtists; ESS62195; ESS62195; TCDM_10166.
DR   VEuPathDB; TriTrypDB:TCDM_10166; -.
DR   Proteomes; UP000017861; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017861};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..440
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..757
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   846 AA;  90866 MW;  E62E12FC1A50026A CRC64;
     MLSRAAAVKA PRTHNRRRVT GSRGMRREGG ESETQRPNMS RHLFYSAVLL LVVMMCCGTG
     GAAEGPEQAS ERNYKWKDIK DEVGGDVTVE SLGVPGLLNV GIDVFAVAEA QCKKSDVIFT
     GIASQLLMKQ TANSPVEVLN GAEGKTQVLE EDGSADPKKK VDVSRPTTVM KGSDIYMLVG
     KYSPAVADTC QEDGGADDWG LLLVKGEVSE ESGSGKRIKW SDNDGLSRIS VGELDSWTEL
     IGSGGSGIET EDGTLVFPVE GTKKENKEGE KAVSLIIHNS KSNAASWKLS KEAPDGGCSD
     PSVVEWEKDK KLIMMTACGD GRRRVYESGD MGDSWTEALG TLSRVWSNKQ GKELKAVRSG
     FITATIGDDN RNVMLVTLPV YSEKDESKKE KGELHLWLTD NTHIVDIGPV SDDDAAASSL
     LYRSGEDGDK EEEELIALYE KKKEGGKPSH SLWSVLLTAQ LQRVKDVLAT WKEVDERVSQ
     LCPSESAEED DDTSPGNACS PPVKITDGLV GFLSGNFSGN TWRDEYLGVN ATVKNNEGGN
     KATMTSDGVK FTGAWAEWPV GSQGENRLYH FANYDFTLVA TVSIHGAPQE EGSPIPLMGA
     RWEGQEENKV FGLSYDSEKR RIVFCGGGTN TEDHSITLAT ETTHQVVLML RNGTQGSAYV
     DGQRVGGDVS CALGNKDSEA VSHFYIGGAK SVSEVQDVSV TVRNVLLYNR PLSTAEIGAL
     NPNKASIPPV VPDNSQVTLS QLSSGGQSPS EQGQQKGSIA AGAGGAFTPA TPXXXGQRTY
     KTARRVANAL NRIFFPFHPS HKAVMFSKGI NRQSTSLGIV SSSIFGPQSS NELIPTFASG
     VFLLPY
//