ID V5AUA5_TRYCR Unreviewed; 864 AA.
AC V5AUA5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS55678.1};
GN ORFNames=TCDM_12835 {ECO:0000313|EMBL:ESS55678.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS55678.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS55678.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS55678.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS55678.1}.
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DR EMBL; AYLP01000716; ESS55678.1; -; Genomic_DNA.
DR AlphaFoldDB; V5AUA5; -.
DR EnsemblProtists; ESS55678; ESS55678; TCDM_12835.
DR VEuPathDB; TriTrypDB:TCDM_12835; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 88..434
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 92298 MW; 801594911C0AE0DE CRC64;
MLSRVAAVKA PRTHNRRRLT GSSGGRREGR ESELQRPNMS RHLFHFVLLL LLVMAFGGSD
AAGVEESAVP QFKWKGITDD EKLDSLGAPS LLKVGNDVFA VAEAQCKEDG GNSFTGIASQ
LLTTQISKTP AEVLEKPEDQ TQVLERDGSE SQNKRVDVSR PTTAVKGNDI YMLVGVYISK
VAVPRQDAKP DATQLGLLLV KGSVSSVEDP SSKKIGWKDT ESSPQKLFEA QLDSWTRLIG
SGGSGVKMED ETLVFPVEGT KKTVGDAEEE GKTVSLIIYS TDNKNWKLSK GMSADGCGSP
SVVEWEGKLM MMTACDGGPR RVYEIDDKEE WTEALGTLSR VWGYKKDVSV VRSGFITATV
GNDGDNKKVM LVTLPVYAEE GNENEKGKLH LWLTDNTHIV DIGSVSDDDA AASSLLYKSG
TGEDKKEELI ALYEKKKGDD EGKPSPGMVS VLLTEQLERV KEVLAAWKKA DDRVSNLCAT
LLAQKDRSTA NACGAVKITD GLVAFLSGKF SDGIWRDEYL GVNATIAEND GAVKAENGVK
FTGRGAGAQW PVGKQGENQL YHFANYNFTL VATVSIHNVP EGSPIPVMGV RAGKEGKTKL
IELSYNSGKK WQVLCGDENS KEHSSGWEKE TQYQVVIMLK NGTQCTVYVD GQRVGDAQCE
LGSGESNDVS HFYIGGDGGS AENKESRGEV SVTVTNVLLY NRPLDEAEIN ALNPNKASTP
SPVDRPEGDE IQPSGGGTEE QRQSLGSSGA GGASTTAVST ITTPSAGEES VMQVVSGSSS
DGHKNVGGGS FSDGDPRVET REGGTNGQEE EVNTQVREVN ATAVSSSLGN VSQENNSDAG
TVCESGLLPS LLLLLLGLWG FAAL
//
