ID V5B226_TRYCR Unreviewed; 495 AA.
AC V5B226;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS61589.1};
GN ORFNames=TCDM_10808 {ECO:0000313|EMBL:ESS61589.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS61589.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS61589.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS61589.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS61589.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000267; ESS61589.1; -; Genomic_DNA.
DR AlphaFoldDB; V5B226; -.
DR EnsemblProtists; ESS61589; ESS61589; TCDM_10808.
DR VEuPathDB; TriTrypDB:TCDM_10808; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 1..147
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 425..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 53122 MW; 6D2245482D5E8F01 CRC64;
MSADGCSDPS VVEWKDKLMM MTACDDGRRR VYESADKGES WTEALGTLSR VWFNKHEGHE
RGVGSGFITA TIEERDVMLV TLPVYAKNAE KGQVNEKGVL HLWLTDNTHI VDIGSVSGDD
DVAASALLYK SAGSGNNHQE ELIALYEKRK GDGESSYSLW SVLLTAQLQR VKKVLATWKE
VDDRVSKLCP ISSTAKDAST ATACSNAIPT DGLVGFLSGE FSDNTWKDEY LGVDATVNKN
DNKGAAKADN GVTFKGRGAW AEWPVGRQGQ NQLYHFANYK FTLVATVSFE GEPKSGSVPL
MGVRAGTGGG TKLMELSYGS GKKWQVLCCD GTTKRLKSTW DTQTQYQVAI VLQNGTQGSV
YVDGQRVCES VQSNFENAES KGISHFYIGG DGGNAENTAG DEGVSVTVGN VLLYNRPLTF
TGGSADLEED IASPSETPVE QAASQQSRKK RETQQVPAVT SSHAVGEKTG DGGIVRGSGL
LPLLLLLGLW GFAAL
//
