ID V5B7R8_TRYCR Unreviewed; 1043 AA.
AC V5B7R8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS60423.1};
GN ORFNames=TCDM_12054 {ECO:0000313|EMBL:ESS60423.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS60423.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS60423.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS60423.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS60423.1}.
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DR EMBL; AYLP01000476; ESS60423.1; -; Genomic_DNA.
DR AlphaFoldDB; V5B7R8; -.
DR EnsemblProtists; ESS60423; ESS60423; TCDM_12054.
DR VEuPathDB; TriTrypDB:TCDM_12054; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR022144; DUF3676.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF12429; DUF3676; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 104..435
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT DOMAIN 728..956
FT /note="DUF3676"
FT /evidence="ECO:0000259|Pfam:PF12429"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..764
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..824
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..855
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 112873 MW; 65A671DCD0295EDF CRC64;
MLSRVAAVMA PRTHNRRRVT GSSGRRREGR ESERQRPNMS RRVFTSAVLL LLVVLMCCGI
GGAATAERGN GKKAVDALLG IKWDKLDNWE DVSNAGGKIT SLRVPGLVKV GDDVFAVAEA
RCGEKDGADS CAGILSKHLD IKGDSMDISM SDMSLFCMKL VDTAENNFGT TEFLRPTTVV
LGDSVYMLVG NQSRTRPQVG GTNERGLLLV KGTVSGEGGK KKIKWNETHL VNPQGKQKSL
SLTELIGGGG SGAVMDDGTL VFPMQAKGKD GTKVLLSMHF PNSVNKWELS SETPGNGCRD
PALVKWEKYE GDNERLFMMA HCAGGYYDVY RSTPHGVNWY PYGEPINRVW GNSHNRKGHG
VQSGSTTAII EGKEVMLITA PVYPKDDGKG RLHLWVTDNA RVYDVGPVSR GEDDAAASSL
LMKEKNNNEL ISLYENKKSG GAYNLVAVRL TEKLERIKEV VKRWKDLDSA LQTRRSGSSG
TVGLPTKGMC NGRVPTDGLV GFLSGNFSEN TWRDEYLGVN ATVTNGKRRV PNGWTFKGPG
AGAVWPVGDM GQTVPYYFAN NKFTLVATVS IHEVPQSDSS PVPLIGVKMN DTKGTVLFGL
SYTHDKKWLA IPENSGNAED SDEWEPNKTY QVVLRMDDSD FWTVFVNREE ILQARYDDHL
FNSHRISHFY IGGDSKNQSA TGGHVTVTNV MLYNERLFDD NLRKLNASKV AIPSLGVEEQ
PTEQAANTGT WVDSESKSVE SATSHEEFTE DDTDEQEEES DDDLVSAASS STAVEGSSVP
EPAIAVKSAE NSHQENNAQL SEGEKSQQST PTEENNSIQQ DSDVHTKELQ SEESAEVADV
EGSSESNEEE MPEEEGGTND RSGESTSQVT ASLSMETTTG PADGEHQVQQ STELPAENDV
RSTGTGTTDA EESLILEAGG SNSERAMNSD SSPTPSRSDA EPTSAENTDN ISRTDGAEVS
SEEGEEAPQT FDTAPGNTST TPGDEAIPSS RDAARHSDND IFNTSEVADL LSTALNHDST
VHVCVSRVLL LLFLGLWGTA ALC
//
