ID V5B8I2_TRYCR Unreviewed; 940 AA.
AC V5B8I2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 26.
DE SubName: Full=Trans-sialidase {ECO:0000313|EMBL:ESS60658.1};
GN ORFNames=TCDM_11805 {ECO:0000313|EMBL:ESS60658.1};
OS Trypanosoma cruzi Dm28c.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=1416333 {ECO:0000313|EMBL:ESS60658.1, ECO:0000313|Proteomes:UP000017861};
RN [1] {ECO:0000313|EMBL:ESS60658.1, ECO:0000313|Proteomes:UP000017861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dm28c {ECO:0000313|EMBL:ESS60658.1,
RC ECO:0000313|Proteomes:UP000017861};
RX PubMed=24482508;
RA Grisard E.C., Teixeira S.M., de Almeida L.G., Stoco P.H., Gerber A.L.,
RA Talavera-Lopez C., Lima O.C., Andersson B., de Vasconcelos A.T.;
RT "Trypanosoma cruzi Clone Dm28c Draft Genome Sequence.";
RL Genome Announc. 2:e01114-13(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESS60658.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYLP01000423; ESS60658.1; -; Genomic_DNA.
DR AlphaFoldDB; V5B8I2; -.
DR EnsemblProtists; ESS60658; ESS60658; TCDM_11805.
DR VEuPathDB; TriTrypDB:TCDM_11805; -.
DR Proteomes; UP000017861; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017861}.
FT DOMAIN 94..441
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 940 AA; 99859 MW; 51F7E5C0DFF89C7B CRC64;
MLSRVAAVMA PRTHNRRRVT GSRGRRREGR ESEPQRPNMS RHLFYSEVLL LIVMMCCGSG
GAAQAAGQAS ERNYKWKDVK NEVGGDVTVE SLGAPGLLNV GSDVFAVAEA QCKKSDVIFT
GMASQLLTID NPDKPVEVLN GAEDKTQVLE EDGSAGSKKK VGVSRPTTVV KGNDIYMIAG
SYSPTDGCQD GADVANLKLL LVKGQVSYEE NKKIHWNDVD ALPCTFLNQE HKSWTRLTGG
GGSGVTMEDG TLLFPVQGTR KVKKEGDTET DEKTVSLIIY SPKATNSWKL SKGMSDGGCS
DPSLVEWGEK GKKLIMMTAC DDGRRRVYEI GDKGESWTEA LGTLSRVWGN KKGEGAKGVR
SGFITATIDG EENNRNVMLV TLPVYPEEEE NGKGELHLWL TDNTHIVDIG PVSDDDAATS
SLLYKSGKSE TNEEELIALY EKKGGKEASH SLWSVRLTAQ LQRVKDVLTT WKEVDETVSK
LCSSSDAKDA SPDNGCSPTV KITDGLVGFL SGNFSDDTWR DEYLGVNATV KGNEGGNKAT
LHEGSVKFTG AWAEWPVGSQ GENQLYHFAN YNFTLVATVS IHGAPKEDIP IPLMGVRAGS
DDKNSVLFGL SYETGKKWKV LCGGENPKEP SSTSKETTHH VVILLRNGTQ GSAYVDGQRV
LGGAQCDLGN TKDKKIPHFY IGGDGSSAGG AGSEEDVSVT VTNVLLYNRP LNSDEIAGIS
KNKITNPKRE GPKTSTSSLS PAASGSVAQQ TVSLPTPAGQ QQTEQYPSTM SSGVGGVGVS
ESRETTVTNP LPGLESAQQL PSVKSSDGSQ SVNASSSSVG DKTVGRGAGD EMQNDETHQP
SMNTPSTADA NIPTAKGVGH DGTVMDQEMN ASSREDEEAT RGTDGQEGIH AQHGEVKAAA
LSSSLGNVSQ GNNSDAGTVR GSGLLPSLPL LLGLWVFAAL
//
