ID V5BAD4_TOXGV Unreviewed; 3951 AA.
AC V5BAD4; A0A0F7V6Y6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=STE kinase {ECO:0000313|EMBL:ESS32495.1};
DE EC=2.7.12.2 {ECO:0000313|EMBL:ESS32495.1};
GN ORFNames=BN1205_066930 {ECO:0000313|EMBL:CEL76526.1}, TGVEG_225960
GN {ECO:0000313|EMBL:ESS32495.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS32495.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS32495.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS32495.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS32495.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS32495.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL76526.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL76526.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
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DR EMBL; LN714500; CEL76526.1; -; Genomic_DNA.
DR EMBL; AAYL02000132; ESS32495.1; -; Genomic_DNA.
DR STRING; 432359.V5BAD4; -.
DR PaxDb; 5811-TGME49_025960; -.
DR EnsemblProtists; ESS32495; ESS32495; TGVEG_225960.
DR VEuPathDB; ToxoDB:TGVEG_225960; -.
DR eggNOG; KOG0582; Eukaryota.
DR OMA; WASTEEQ; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004708; F:MAP kinase kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR48012:SF35; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48012; STERILE20-LIKE KINASE, ISOFORM B-RELATED; 1.
DR Pfam; PF00069; Pkinase; 3.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000313|EMBL:ESS32495.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transferase {ECO:0000313|EMBL:ESS32495.1}.
FT DOMAIN 1558..1961
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 849..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1233..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1603..1637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1748..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2090..2390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2406..2530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2566..2723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2738..3023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3057..3148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3164..3194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3232..3261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3273..3321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3346..3387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3405..3426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3494..3552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3628..3648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3674..3739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3911..3951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 866..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2225..2241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2327..2357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2364..2383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2414..2429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2468..2516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2569..2589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2622..2638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2647..2661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2746..2762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2837..2868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2891..2915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2949..3023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3367..3387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3682..3700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3927..3942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3951 AA; 412024 MW; 8E0A0D92FC30E033 CRC64;
MPNEHPSSAT SGRQCPQNWA PEENALLGSS GKSAFFASSS SSSTALTSHV PRHYSSHGRP
PRSTTRVDSL GFQAGEPRLS SSTLEKSGVT TLNAPSDTSE ISVKSKVAPG HGGQSQTSSS
PPECFPTAVF PLATPLLLPT GLPFLQDAAD SGFPVGFQRS VPTGPQAVIS AVRPTSRSAA
FYAQSRDISP GTLQFTYHLP HSSLQSRSTE GLPHTRQKVP VRRFSGQSCG VNEAASDKHS
NRSVSPGSPS TVNQRYSSRP LSRQTKSLHP SPRSPQVVAE FCSKTGSSFS IPQERSESSG
AGRRMRFEHL PPSTAAPSSP RRSLHLPPLP VSRDQALTSP LESATLTYPR TCGERSKNEA
LPRNSRQATS LHAPQLPGRA ERKAGGRDWG VLELPKLQVA TPRAKSGSAA EETGLSFCES
SRGQSPFRTH TPGTESLPGD ARSSAPAQGE NLVPAWQNEI LEERASGHRS EDPVPRAGAK
EPSPLWGVQG GLRPRSRSGA SLTSSDPLLG SAQTEAFAHR GFVSLGPAVR NAALVESEVQ
RLALERACQS QDNVVAESSL STSSRASQST APSDSRLILQ AYAEGLTPSP WFAAPSPWSP
EAGAGRALPA YSPSPAWSLP PIPPTAIWHA PPSGVADLQG VSGSLPAPRR PPGSLGPHPK
SGRPPEFRGV SPACAAESPN SCDSCGAAAD RRGGASRADR GQDAERDEAA AVGAQREGTG
LSAGLPPSRP AVASAGLSTG ERKRRDIARR GPSGETDLER IESFESIDST NFAPVSEGSQ
SREKADNGHQ AGTTSASSGW ASTEEQEMTN KPQTDPGGRG AAVLDYNLDS RPAVDSRLVS
DSIRASDSRL VSDSRLVSDS RPVSDSVSLR VRESRGGHRV QVDTEVERLE RSEKGERHAV
TSGLPLSVGA ERKQRLASAA EPVGALSGTV VGCVERMETK EEDRRSPLEP SSRMDAGSGS
LPLSSPPPKA AARGTGGVGA PPTPSKESSI RYTYASSSRA SRGDASSASQ SPHASPERLR
GKGVAGVVCA ASPQRERRRD LRAATPLQRS LVVSSPSRSM FSFASPQGAV SVSVAKSRRS
RSRVQSAGGE KKPGDSSGRG RRGPRREQEG NRSASGHGLH LSTLGGFSPR SAGSPRAEGP
LRLSASGQYP ASTPLQRAEK KGEDVDNLIF WSPPPHQVSP HFPQNSGWGG TSPPPRVFSP
CFPVSFLPVS GSATSSPPLS ASPHRAFEPS SPLPSLVFLS PRHTQSTPPT PASLVSPPRS
LPLQQAASSD LAASPAHSRV LRSSGVGLAP PSLAQLEDVL GLRTKDTASL PFAATPESPA
ALPHRMQVAT LGAADLGRTA FPWERDLRGP APHEAAGLDP AASLASGASE VLPRSTASAG
VSGLNAPKKK DPQALHHAAV IACVSRLVES FPPSSELHNG YGPLTIPPHW LATYAPTSRD
MQKYAAEFQQ TRIASASVHR ETNGSEHRDG LREQEDQAEG KEEGRKEAEG VDFAGGGSAT
VGEEGCERAP GLSDGSGEVR IEKRLEEWVR LGGNLGEFER IFDLQLPAVS FAAPSAVYVV
EELVGKGAHG AVFKCTRYRK AARPEEKTGG SFLGAFGKKV SEAREKKAEE TRPGVERPEG
ARQVSDGDER DGAEEDVEED EVALKIIDLD GALQLQGATD KEARVNYLNQ VMREVDVLKQ
CNHEGIVKMY EAFQWPPCYL VFSMELLPGG SLRDLYASAG PLPEPLIAAL LQDVLKALKY
LHNGGEAEAA GAKNEGKHKN AEQVGARPEA EETGDGPSAE AARAAKQPRR MHRDLKASNI
LISAEGRAKL IDFGVCADIT DSLCTEFVGT PQWMAPELAR LGVEMGRRKQ ESSRDLPGPS
SLEQTRKSLK SPGFGASEGY DFRVDLWALG ITAYEVAVGS LPWPRRMRLE DLLGTILEGS
PPRINLNEGY EKTFCFFVER CLRKNSEERG TATELLQHPF FKKFCASSRS RPASHQELRE
AIEVANGKRK ANVLSNLLKF IPFFRKPQPT NGRKKGTCSR LHRFKIGRQA IHGSQSMDRG
KLEAELAAHG TCSPATTGQC APNLDVFTHH PTAEPQAFRG NHDSLFSQVA WPHQPSLPSP
RGSGGSAELR VGDASRSLHF ASGVRDGEPQ LPAQTRRGGD SEATGPFLQD PRPCRSDTLE
TSPLPGPCAN AELSKEVRDP ADAAPETVNA GESSEPSPPE DCVAGLRQPR GEGSEEAVQE
GQTATVDRTR ERERHSIVWA KNLEGARDPR VAATTDCMQS ALRSDEDGDK GDSTPSAQLL
EEPQSCYGTP KNEGFPAEPS LGDCGATSEA PAVRGEDLVL GATFHDIPEG AEKREEVQRT
ETEAVEDWKE TEGSDGKEDA GTASLAVGEK RDERRDLHTP ESCEGAREAQ TGGFFASLFS
NVGLGIFGES STHAGLDQRE EESGKAETTS DFESPRSSSA ASLFGLKRDD TDLHDDTCVP
GTNDPIEPCS TPPSSSSSSS SSPSSSSSSS SSSSSSSSSS SSSSSSVPSS LSRGESEDGS
RFAPPSLPVS VSAFGSTEVQ VIACGPSEGG SSRVALHPVL LMRRAGSEEK ANASSSASSF
PTPSAGTVSV CPGRTGPLLR RRCRKGREGR ASLLATEKGR DGVGAQKAEK EHKTSHLKAN
PSIPKPAAPF ASTSSPSVSQ GKKAGEGGLL SLFRRSPEDP GSFVETAAAA PSEAKGEPSP
SGGALEPNGP EAAPQSPSPT DSALSFLVQL FGARREIRGA GEGAVPGETS TQTETLCTGE
SLPTEEGENA EERSDDGVQW AELLEPHGGD EPVAEGEEES MLLSSLERVP SRRFSEESGS
LGEASEGQGL QPQAPERAGR EGEEREEGDI EVKEEGVVGE RGEQKDEARA AAPSGNLDAA
AVNTGMPGLA ETDGEREREP QEEQSSEESS SKGETHATHD GASPLAWLWP FGRSVSGMAA
PPPFPRASSS SPEASSTSSS SSTSNSSLPS ASSSSSLPSA SSYSTSSASS SSSMGSCSLA
PALATSSSSS SSSSASSSTA EPVGETHFCA MLESPTIQGN SVSGGLEALQ KCRVLPKTHA
DSGEAGARGS APKPPAALLQ APEAESSPSP GGGRQGDAPA ACQDGEAHLS GSAAAASGAA
VSEPAGERAA QETSERKGES SLSSPTRWPS LLYKSLVDGW TGGANAARKQ EEPNGGLGGP
EASATSEEAV ETRQNLVSVG RSDGACVATG HGTSLWSGSE RFAAGGRISL PAGWGVWEPP
REGRTSAGTG YVQASPPSHA SPCAAPVDAL CGSTGPTGSG EPWSALPGWG AGGPLGPRGK
EEAQRQEGTK PTRRLGLPPF PDLVSMPASF AVEAHCLGTE EVKAWAGQER REEDLKKAPR
LPAASLGGRN ASSQGRGSGE EHSRALSQVQ YSQATSCSSP VFWAQSGQGA GDQGAEGSGD
SMWGGSCSFS TDGVAGVGSS RAGETPQGVA AGAVSCADQP TVPFPAVAFS GFSSSAPHSY
LSSSLATQPT GATVACGPGA PPGGAGRQGG RDRPAASVPA FSELQSPCGT KTGESLKGAS
VRGDAQEAQT VKREELDDLR PAEGVQRHFQ IVQATRPDGC VDAKLLRLIQ ETYNRKLDRR
YQAQSLGGAH APPSQQELVW NPTQRRRSLG PALTAPSSGQ GTQATVPAAS VEKNGSAIPP
MPYGFAAVLQ GAGPPLPSGG SPKQRAVSQD FSSAANSGES GRPSRARLHE LAEREAASLP
AAESRVARPV RPLAPSHERG PLLVRLPSPC TLVSGGSSAS ETFPAENISG ERRAFPSVHT
PGGPGCSGLA HVPSVSRAQS GGFPDTLAAR GSVPRAGVEP RCFVPGADAV SAWNGSSGEA
RSLPQSVAGA AACAVQTAAP PGIPRPAPQV YIRAGGGPVS PYPGQSGNAG HILPPTDYAG
KRVFQAERQV APAAVEPASG RQGRRAPTAD ETVRREQQRS KGSAKHFAAS E
//
